Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria

• Alexandra Bick ,

  Contributed equally to this work with: Alexandra Bick, Willem Buys

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

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• Willem Buys ,

  Contributed equally to this work with: Alexandra Bick, Willem Buys

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: w.buys@ymail.com

  Affiliation Universität Duisburg-Essen, Essen, Germany

  https://orcid.org/0000-0002-4482-7750

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• Andrea Engler,

  Roles Investigation

  Affiliation Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

  ⨯
• Rabea Madel,

  Roles Methodology

  Affiliation Universität Duisburg-Essen, Essen, Germany

  ⨯
• Mazen Atia,

  Roles Investigation

  Affiliation Universität Duisburg-Essen, Essen, Germany

  ⨯
• Francesca Faro,

  Roles Methodology

  Affiliation Universität Duisburg-Essen, Essen, Germany

  ⨯
• Astrid M. Westendorf,

  Roles Methodology

  Affiliation Institut für Medizinische Mikrobiologie, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

  ⨯
• Andreas Limmer,

  Roles Investigation

  Affiliation Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

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• Jan Buer,

  Roles Resources, Supervision

  Affiliation Institut für Medizinische Mikrobiologie, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

  ⨯
• Frank Herbstreit,

  Roles Resources

  Affiliation Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

  ⨯
• Carsten J. Kirschning ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ CJK and JP also contributed equally to this work.

  Affiliation Institut für Medizinische Mikrobiologie, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

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• Jürgen Peters

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  ¶‡ CJK and JP also contributed equally to this work.

  Affiliation Klinik für Anästhesiologie und Intensivmedizin, Universität Duisburg Essen & Universitätsklinikum Essen, Essen, Germany

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