Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

• Ziva Pogacar,

  Roles Conceptualization, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0003-3240-9233

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• Jackie L. Johnson,

  Roles Conceptualization, Investigation, Validation

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Lenno Krenning,

  Roles Investigation, Methodology, Validation, Visualization

  Affiliation Division of Cell Biology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0001-6696-0512

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• Giulia De Conti,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-2647-228X

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• Fleur Jochems,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Cor Lieftink,

  Roles Data curation, Formal analysis, Software, Visualization

  Affiliation The NKI Robotics and Screening Center, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Arno Velds,

  Roles Data curation, Formal analysis, Software, Visualization

  Affiliation Genomics Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Leyma Wardak,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-8535-9607

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• Kelvin Groot,

  Roles Formal analysis, Investigation, Software, Visualization

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0001-7177-938X

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• Arnout Schepers,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Liqin Wang,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-9881-6432

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• Ji-Ying Song,

  Roles Formal analysis, Investigation

  Affiliation Division of Animal Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Marieke van de Ven,

  Roles Supervision

  Affiliation Mouse Clinic for Cancer and Aging, Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Olaf van Tellingen,

  Roles Supervision

  Affiliation Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-1037-6269

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• Rene H. Medema,

  Roles Funding acquisition, Supervision

  Affiliation Division of Cell Biology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Roderick L. Beijersbergen,

  Roles Supervision, Writing – review & editing

  Affiliations Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands, The NKI Robotics and Screening Center, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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• Rene Bernards ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  * E-mail: r.bernards@nki.nl (RB); r.ld.oliveira@amsterdamumc.nl (RLO)

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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•  [ ... ],
• Rodrigo Leite de Oliveira

  Roles Conceptualization, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: r.bernards@nki.nl (RB); r.ld.oliveira@amsterdamumc.nl (RLO)

  Current Address: CRISPR Expertise Center, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands

  Affiliation Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-9696-2014

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