Bayesian and frequentist approaches to sequential monitoring for futility in oncology basket trials: A comparison of Simon’s two-stage design and Bayesian predictive probability monitoring with information sharing across baskets

• Alexander Kaizer ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: alex.kaizer@cuanschutz.edu

  Affiliation Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado-Anschutz Medical Campus, Aurora, CO, United States of America

  https://orcid.org/0000-0003-2334-5514

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• Emily Zabor,

  Roles Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Quantitative Health Sciences & Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, United States of America

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• Lei Nie,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Division of Biometrics II, Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, United States of America

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• Brian Hobbs

  Roles Conceptualization, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Population Health, University of Texas-Austin, Austin, TX, United States of America

  https://orcid.org/0000-0003-2189-5846

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