Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway

• Mohammed S. Taghour,

  Roles Methodology

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  https://orcid.org/0000-0003-0630-709X

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• Hazem Elkady,

  Roles Software, Writing – original draft

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

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• Wagdy M. Eldehna,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

  https://orcid.org/0000-0001-6996-4017

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• Nehal El-Deeb,

  Roles Data curation, Formal analysis, Methodology

  Affiliations Biopharmaceutical Products Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt, Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications (SRTA City), Alexandria, Egypt

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• Ahmed M. Kenawy,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Nucleic Acids Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Alexandria, Egypt

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• Eslam B. Elkaeed,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia

  https://orcid.org/0000-0002-2546-8035

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• Bshra A. Alsfouk,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

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• Mohamed S. Alesawy,

  Roles Formal analysis, Investigation, Writing – original draft

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

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• Dalal Z. Husein,

  Roles Methodology, Validation

  Affiliation Chemistry Department, Faculty of Science, New Valley University, El-Kharja, Egypt

  https://orcid.org/0000-0001-7552-0914

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• Ahmed M. Metwaly ,

  Roles Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: Ibrahimeissa@azhar.edu.eg (IHE); ametwaly@azhar.edu.eg (AMM)

  Affiliations Pharmaceutical and Fermentation Industries Development Center, City of Scientific Research and Technological Applications (SRTA City), Alexandria, Egypt, Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  https://orcid.org/0000-0001-8566-1980

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• Ibrahim H. Eissa

  Roles Conceptualization, Investigation, Project administration, Supervision, Writing – review & editing

  * E-mail: Ibrahimeissa@azhar.edu.eg (IHE); ametwaly@azhar.edu.eg (AMM)

  Affiliation Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

  https://orcid.org/0000-0002-6955-2263

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