OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy

• Hikari Yamamoto,

  Roles Formal analysis, Investigation, Writing – original draft

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Yasuyuki Nagumo,

  Roles Investigation, Writing – review & editing

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Yukiko Ishikawa,

  Roles Investigation

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Yoko Irukayama-Tomobe,

  Roles Investigation

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Yukiko Namekawa,

  Roles Investigation

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Tsuyoshi Nemoto,

  Roles Investigation

  Affiliation School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Hiromu Tanaka,

  Roles Investigation

  Affiliation School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Genki Takahashi,

  Roles Investigation

  Affiliation School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Akihisa Tokuda,

  Roles Investigation

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Tsuyoshi Saitoh,

  Roles Resources

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Hiroshi Nagase,

  Roles Supervision

  Affiliation International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Hiromasa Funato,

  Roles Supervision

  Affiliations International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan, Department of Anatomy, Faculty of Medicine, Toho University, Ota-ku, Tokyo, Japan

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• Masashi Yanagisawa

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: yanagisawa.masa.fu@u.tsukuba.ac.jp

  Affiliations International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan, R&D Center for Frontiers of MIRAI in Policy and Technology, University of Tsukuba, Tsukuba, Ibaraki, Japan

  https://orcid.org/0000-0002-7358-4022

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