Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells

YongYao Xu; Michael Twarog; Ning Li; Angela Banks; Josh Schustak; Yi Bao; Qian Huang; Quintus G. Medley

doi:10.1371/journal.pone.0271656

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Open Access

Peer-reviewed

Research Article

Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells

YongYao Xu ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

* E-mail: yongyao.xu@novartis.com (YX); medleyq@gmail.com, qmedley@its.jnj.com (QGM)

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America
⨯
Michael Twarog,

Roles Investigation, Methodology

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America
⨯
Ning Li,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America
⨯
Angela Banks,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America
⨯
Josh Schustak,

Roles Investigation, Methodology

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America
⨯
Yi Bao,

Roles Formal analysis, Investigation

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America
⨯
Qian Huang,

Roles Conceptualization, Writing – review & editing

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America
⨯
Quintus G. Medley

Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

* E-mail: yongyao.xu@novartis.com (YX); medleyq@gmail.com, qmedley@its.jnj.com (QGM)

Affiliation Department of Ophthalmology, Novartis Institutes of Biomedical Research, Cambridge, MA, United States of America

https://orcid.org/0000-0002-4646-3532

⨯

Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells

YongYao Xu,
Michael Twarog,
Ning Li,
Angela Banks,
Josh Schustak,
Yi Bao,
Qian Huang,
Quintus G. Medley

Published: July 28, 2022
https://doi.org/10.1371/journal.pone.0271656

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Signal inhibition
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Inflammation
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Zinc
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