Immune suppression is associated with enhanced systemic inflammatory, endothelial and procoagulant responses in critically ill patients

• Xanthe Brands ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: x.brands@amsterdamumc.nl

  ¶‡ XB and FU share first authorship on this work.

  Affiliation Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands

  https://orcid.org/0000-0003-3137-6708

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• Fabrice Uhel ,

  Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

  ¶‡ XB and FU share first authorship on this work.

  Affiliation Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Lonneke A. van Vught,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Maryse A. Wiewel,

  Roles Data curation, Writing – review & editing

  Affiliation Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Arie J. Hoogendijk,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• René Lutter,

  Roles Data curation, Writing – review & editing

  Affiliation Respiratory Medicine and Experimental Immunology, Amsterdam University Medical Centers—Location AMC, Amsterdam, The Netherlands

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• Marcus J. Schultz,

  Roles Writing – review & editing

  Affiliations Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

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• Brendon P. Scicluna,

  Roles Writing – review & editing

  Affiliations Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands, Department of Applied Biomedical Science, Faculty of Health Sciences, Mater Dei Hospital, University of Malta, Msida, Malta, Centre for Molecular Medicine and Biobanking, University of Malta, Msida, Malta

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• Tom van der Poll

  Roles Formal analysis, Funding acquisition, Supervision

  Affiliations Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands, Division of Infectious Diseases, Amsterdam University Medical Centers—Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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