Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn²⁺-dependent amidases

• Jae Kyo Yi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, United States of America

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States of America

  https://orcid.org/0000-0001-7053-601X

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• Ruijuan Xu,

  Roles Investigation, Methodology

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook, NY, United States of America

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• Lina M. Obeid,

  Roles Conceptualization, Funding acquisition, Supervision

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook, NY, United States of America

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• Yusuf A. Hannun,

  Roles Funding acquisition, Project administration, Supervision

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook, NY, United States of America

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• Michael V. Airola ,

  Contributed equally to this work with: Michael V. Airola, Cungui Mao

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Software, Supervision, Writing – review & editing

  * E-mail: Cungui.Mao@stonybrookmedicine.edu (CM); Michael.Airola@stonybrook.edu (MVA)

  Affiliation Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States of America

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• Cungui Mao

  Contributed equally to this work with: Michael V. Airola, Cungui Mao

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: Cungui.Mao@stonybrookmedicine.edu (CM); Michael.Airola@stonybrook.edu (MVA)

  Affiliations Department of Medicine, Stony Brook University, Stony Brook, NY, United States of America, Stony Brook Cancer Center, Stony Brook, NY, United States of America

  https://orcid.org/0000-0002-1330-1887

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