13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico

• Douglas Kemboi ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

  * E-mail: kemboidouglas01@gmail.com (DK); TembuVJ@tut.ac.za (JT)

  Affiliations Department of Chemistry, Tshwane University of Technology, Pretoria, South Africa, Department of Chemistry, Rhodes University, Makhanda (Grahamstown), South Africa

  https://orcid.org/0000-0003-3771-128X

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• Moses K. Langat,

  Roles Validation, Writing – review & editing

  Affiliation Royal Botanic Gardens Kew, Kew Green, Richmond, Surrey, United Kingdom

  https://orcid.org/0000-0001-8079-7774

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• Xavier Siwe-Noundou,

  Roles Resources, Validation, Writing – review & editing

  Affiliation Pharmaceutical Sciences Department, Sefako Makgatho Health Sciences University, Pretoria, South Africa

  https://orcid.org/0000-0002-8667-8351

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• Tendamudzimu Tshiwawa,

  Roles Data curation, Methodology, Software

  Affiliation Department of Chemistry, Rhodes University, Makhanda (Grahamstown), South Africa

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• Rui W. M. Krause,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Chemistry, Rhodes University, Makhanda (Grahamstown), South Africa

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• Candace Davison,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Biochemistry and Microbiology, Rhodes University, Makhanda (Grahamstown), South Africa

  https://orcid.org/0000-0002-8288-9290

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• Christie Jane Smit,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Microbiology, Rhodes University, Makhanda (Grahamstown), South Africa

  https://orcid.org/0000-0002-7190-175X

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• Jo-Anne de la Mare,

  Roles Data curation, Project administration, Validation, Writing – review & editing

  Affiliation Department of Biochemistry and Microbiology, Rhodes University, Makhanda (Grahamstown), South Africa

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• Vuyelwa Jacqueline Tembu

  Roles Data curation, Resources, Supervision, Writing – review & editing

  * E-mail: kemboidouglas01@gmail.com (DK); TembuVJ@tut.ac.za (JT)

  Affiliation Department of Chemistry, Tshwane University of Technology, Pretoria, South Africa

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