Predictive model for severe COVID-19 using SARS-CoV-2 whole-genome sequencing and electronic health record data, March 2020-May 2021

Lei Zhu; Jane W. Marsh; Marissa P. Griffith; Kevin Collins; Vatsala Srinivasa; Kady Waggle; Daria Van Tyne; Graham M. Snyder; Tung Phan; Alan Wells; Oscar C. Marroquin; Lee H. Harrison

doi:10.1371/journal.pone.0271381

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Open Access

Peer-reviewed

Research Article

Predictive model for severe COVID-19 using SARS-CoV-2 whole-genome sequencing and electronic health record data, March 2020-May 2021

Lei Zhu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0002-7318-4387

⨯
Jane W. Marsh,

Roles Methodology, Project administration, Resources, Writing – review & editing

Affiliations Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Marissa P. Griffith,

Roles Formal analysis, Software, Visualization, Writing – review & editing

Affiliations Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Kevin Collins,

Roles Data curation, Resources

Affiliation Healthcare Data and Analytics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Vatsala Srinivasa,

Roles Project administration, Resources

Affiliations Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Kady Waggle,

Roles Project administration, Resources

Affiliations Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Daria Van Tyne,

Roles Methodology, Writing – review & editing

Affiliations Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0001-7284-0103

⨯
Graham M. Snyder,

Roles Methodology, Writing – review & editing

Affiliations Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Infection Prevention and Control, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Tung Phan,

Roles Data curation, Writing – review & editing

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Alan Wells,

Roles Resources, Writing – review & editing

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0002-1637-8150

⨯
Oscar C. Marroquin,

Roles Data curation, Resources, Writing – review & editing

Affiliation Healthcare Data and Analytics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Lee H. Harrison

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – review & editing

* E-mail: lharriso@edc.pitt.edu

Affiliations Microbial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0002-3787-2705

⨯

Predictive model for severe COVID-19 using SARS-CoV-2 whole-genome sequencing and electronic health record data, March 2020-May 2021

Lei Zhu,
Jane W. Marsh,
Marissa P. Griffith,
Kevin Collins,
Vatsala Srinivasa,
Kady Waggle,
Daria Van Tyne,
Graham M. Snyder,
Tung Phan,
Alan Wells

Published: July 12, 2022
https://doi.org/10.1371/journal.pone.0271381

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