Fitness cost of target-site and metabolic resistance to pyrethroids drives restoration of susceptibility in a highly resistant Anopheles gambiae population from Uganda

Magellan Tchouakui; Ambrose Oruni; Tatiane Assatse; Claudine R. Manyaka; Micareme Tchoupo; Jonathan Kayondo; Charles S. Wondji

doi:10.1371/journal.pone.0271347

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Peer-reviewed

Research Article

Fitness cost of target-site and metabolic resistance to pyrethroids drives restoration of susceptibility in a highly resistant Anopheles gambiae population from Uganda

Magellan Tchouakui ,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: magellan.tchouakui@crid-cam.net (MT); charles.wondji@lstmed.ac.uk (CSW)

Affiliation Centre for Research in Infectious Diseases (CRID), Yaoundé, Cameroon

https://orcid.org/0000-0002-1683-8057

⨯
Ambrose Oruni,

Roles Investigation

Affiliations Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Entomology Department, Uganda Virus Research Institute (UVRI), Entebbe, Uganda
⨯
Tatiane Assatse,

Roles Investigation

Affiliations Centre for Research in Infectious Diseases (CRID), Yaoundé, Cameroon, Parasitology and Ecology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon
⨯
Claudine R. Manyaka,

Roles Investigation

Affiliations Centre for Research in Infectious Diseases (CRID), Yaoundé, Cameroon, Parasitology and Ecology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon

https://orcid.org/0000-0001-7095-9952

⨯
Micareme Tchoupo,

Roles Investigation

Affiliation Centre for Research in Infectious Diseases (CRID), Yaoundé, Cameroon
⨯
Jonathan Kayondo,

Roles Supervision

Affiliation Entomology Department, Uganda Virus Research Institute (UVRI), Entebbe, Uganda
⨯
Charles S. Wondji

Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – review & editing

* E-mail: magellan.tchouakui@crid-cam.net (MT); charles.wondji@lstmed.ac.uk (CSW)

Affiliations Centre for Research in Infectious Diseases (CRID), Yaoundé, Cameroon, Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, International Institute of Tropical Agriculture (IITA), Yaoundé, Cameroon
⨯

Fitness cost of target-site and metabolic resistance to pyrethroids drives restoration of susceptibility in a highly resistant Anopheles gambiae population from Uganda

Magellan Tchouakui,
Ambrose Oruni,
Tatiane Assatse,
Claudine R. Manyaka,
Micareme Tchoupo,
Jonathan Kayondo,
Charles S. Wondji

Published: July 26, 2022
https://doi.org/10.1371/journal.pone.0271347

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