Sex-, age-, and organ-dependent improvement of bile acid hydrophobicity by ursodeoxycholic acid treatment: A study using a mouse model with human-like bile acid composition

• Hajime Ueda,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliation Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

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• Akira Honda ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – original draft

  * E-mail: akihonda@tokyo-med.ac.jp

  Affiliations Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan, Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

  https://orcid.org/0000-0003-0902-8272

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• Teruo Miyazaki,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

  https://orcid.org/0000-0001-9796-3011

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• Yukio Morishita,

  Roles Investigation

  Affiliation Diagnostic Pathology Division, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

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• Takeshi Hirayama,

  Roles Funding acquisition

  Affiliation Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

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• Junichi Iwamoto,

  Roles Funding acquisition

  Affiliation Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

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• Nobuhiro Nakamoto,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Internal Medicine, Division of Gastroenterology and Hepatology, Keio University School of Medicine, Tokyo, Japan

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• Tadashi Ikegami

  Roles Funding acquisition, Writing – review & editing

  Affiliation Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan

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