Utilizing virtual experiments to increase understanding of discrepancies involving in vitro-to-in vivo predictions of hepatic clearance

• Preethi Krishnan ,

  Contributed equally to this work with: Preethi Krishnan, Andrew K. Smith

  Roles Data curation, Formal analysis, Investigation, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: The Interdisciplinary Bioengineering Graduate Program, School of Electrical and Computer Engineering, Atlanta, GA, United States of America

  Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

  https://orcid.org/0000-0002-2296-4594

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• Andrew K. Smith ,

  Contributed equally to this work with: Preethi Krishnan, Andrew K. Smith

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

  ⨯
• Glen E. P. Ropella,

  Roles Conceptualization, Data curation, Methodology, Resources, Software, Validation, Writing – review & editing

  Affiliation Tempus Dictum, Inc., Olympia, WA, United States of America

  https://orcid.org/0000-0002-6031-105X

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• Lopamudra Dutta,

  Roles Writing – original draft, Writing – review & editing

  Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

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• Ryan C. Kennedy,

  Roles Writing – review & editing

  Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

  https://orcid.org/0000-0003-2146-4026

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• C. Anthony Hunt

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: a.hunt@ucsf.edu

  Affiliation Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States of America

  https://orcid.org/0000-0001-9372-6860

  ⨯