Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613

Moises O. Guardado Rivas; Shawn D. Stuart; Daniel Thach; Michael Dahan; Robert Shorr; Zuzana Zachar; Paul M. Bingham

doi:10.1371/journal.pone.0269620

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Peer-reviewed

Research Article

Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613

Moises O. Guardado Rivas ,

Contributed equally to this work with: Moises O. Guardado Rivas, Shawn D. Stuart

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States of America, Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, United States of America, Rafael Pharmaceuticals, Cranbury, NJ, United States of America
⨯
Shawn D. Stuart ,

Contributed equally to this work with: Moises O. Guardado Rivas, Shawn D. Stuart

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

Affiliations Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States of America, Rafael Pharmaceuticals, Cranbury, NJ, United States of America
⨯
Daniel Thach,

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliation Rafael Pharmaceuticals, Cranbury, NJ, United States of America
⨯
Michael Dahan,

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliation Rafael Pharmaceuticals, Cranbury, NJ, United States of America
⨯
Robert Shorr,

Roles Methodology

Affiliation Rafael Pharmaceuticals, Cranbury, NJ, United States of America
⨯
Zuzana Zachar,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States of America
⨯
Paul M. Bingham

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft

* E-mail: paul.bingham@stonybrook.edu

Affiliation Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States of America

https://orcid.org/0000-0002-8927-1872

⨯

Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613

Moises O. Guardado Rivas,
Shawn D. Stuart,
Daniel Thach,
Michael Dahan,
Robert Shorr,
Zuzana Zachar,
Paul M. Bingham

Published: June 8, 2022
https://doi.org/10.1371/journal.pone.0269620

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