Familial hemophagocytic lymphohistiocytosis hepatitis is mediated by IFN-γ in a predominantly hepatic-intrinsic manner

Tamir Diamond; Thomas N. Burn; Mailyn A. Nishiguchi; Danielle Minichino; Julie Chase; Niansheng Chu; Portia A. Kreiger; Edward M. Behrens

doi:10.1371/journal.pone.0269553

Loading metrics

Open Access

Peer-reviewed

Research Article

Familial hemophagocytic lymphohistiocytosis hepatitis is mediated by IFN-γ in a predominantly hepatic-intrinsic manner

Tamir Diamond ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Validation, Writing – original draft, Writing – review & editing

* E-mail: diamondt@chop.edu

Affiliation Division of Gastroenterology Hepatology and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America

https://orcid.org/0000-0002-1904-5351

⨯
Thomas N. Burn,

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Mailyn A. Nishiguchi,

Roles Formal analysis, Software, Writing – review & editing

Affiliation Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America

https://orcid.org/0000-0002-7151-6085

⨯
Danielle Minichino,

Roles Data curation, Writing – review & editing

Affiliation Perlman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Julie Chase,

Roles Data curation, Writing – review & editing

Affiliation Division of Rheumatology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Niansheng Chu,

Roles Data curation, Writing – review & editing

Affiliation Division of Rheumatology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Portia A. Kreiger,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Pathology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯
Edward M. Behrens

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Division of Rheumatology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
⨯

Familial hemophagocytic lymphohistiocytosis hepatitis is mediated by IFN-γ in a predominantly hepatic-intrinsic manner

Tamir Diamond,
Thomas N. Burn,
Mailyn A. Nishiguchi,
Danielle Minichino,
Julie Chase,
Niansheng Chu,
Portia A. Kreiger,
Edward M. Behrens

Published: June 7, 2022
https://doi.org/10.1371/journal.pone.0269553

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
White blood cells
Is the Subject Area "White blood cells" applicable to this article?

Thanks for your feedback.
Immune response
Is the Subject Area "Immune response" applicable to this article?

Thanks for your feedback.
Hepatitis
Is the Subject Area "Hepatitis" applicable to this article?

Thanks for your feedback.
Monocytes
Is the Subject Area "Monocytes" applicable to this article?

Thanks for your feedback.
CD coreceptors
Is the Subject Area "CD coreceptors" applicable to this article?

Thanks for your feedback.