Changes in the development of opioid tolerance on re-exposure among people who use heroin: A qualitative study

Joanna May Kesten; Ed Holder; Rachel Ayres; Pete Ellis; Steve Taylor; Matthew Hickman; Graeme Henderson

doi:10.1371/journal.pone.0269379

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Open Access

Peer-reviewed

Research Article

Changes in the development of opioid tolerance on re-exposure among people who use heroin: A qualitative study

Joanna May Kesten ,

Roles Data curation, Formal analysis, Methodology, Writing – original draft

* E-mail: Jo.Kesten@bristol.ac.uk

Affiliations NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom, NIHR Applied Research Collaboration (ARC) West at University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

https://orcid.org/0000-0002-3674-6045

⨯
Ed Holder,

Roles Data curation, Supervision, Writing – review & editing

Affiliation Bristol Drugs Project, Bristol, United Kingdom
⨯
Rachel Ayres,

Roles Supervision, Writing – review & editing

Affiliation Bristol Drugs Project, Bristol, United Kingdom
⨯
Pete Ellis,

Roles Conceptualization, Writing – review & editing

Affiliations Bristol Drugs Project, Bristol, United Kingdom, Developing Health and Independence, Brunswick Court, Bristol, United Kingdom
⨯
Steve Taylor,

Roles Supervision, Writing – review & editing

Affiliation Alcohol & Drugs Treatment & Recovery, Office for Health Improvement and Disparities, Department of Health and Social Care, London, United Kingdom

https://orcid.org/0000-0002-9735-5611

⨯
Matthew Hickman,

Roles Supervision, Writing – review & editing

Affiliations NIHR Health Protection Research Unit in Behavioural Science and Evaluation, University of Bristol, Oakfield House, Oakfield Grove, Bristol, United Kingdom, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom
⨯
Graeme Henderson

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

Affiliation School of Physiology, Pharmacology & Neuroscience, University of Bristol, University Walk, Bristol, United Kingdom
⨯

Changes in the development of opioid tolerance on re-exposure among people who use heroin: A qualitative study

Joanna May Kesten,
Ed Holder,
Rachel Ayres,
Pete Ellis,
Steve Taylor,
Matthew Hickman,
Graeme Henderson

Published: June 23, 2022
https://doi.org/10.1371/journal.pone.0269379

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