High HIV incidence among young women in South Africa: Data from a large prospective study

Thesla Palanee-Phillips; Helen V. Rees; Kate B. Heller; Khatija Ahmed; Joanne Batting; Ivana Beesham; Renee Heffron; Jessica Justman; Heeran Makkan; Timothy D. Mastro; Susan A. Morrison; Nelly Mugo; Gonasagrie Nair; James Kiarie; Neena M. Philip; Melanie Pleaner; Krishnaveni Reddy; Pearl Selepe; Petrus S. Steyn; Caitlin W. Scoville; Jenni Smit; Katherine K. Thomas; Deborah Donnell; Jared M. Baeten; for the ECHO Trial Consortium

doi:10.1371/journal.pone.0269317

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Open Access

Peer-reviewed

Research Article

High HIV incidence among young women in South Africa: Data from a large prospective study

Thesla Palanee-Phillips ,

Contributed equally to this work with: Thesla Palanee-Phillips, Kate B. Heller, Jared M. Baeten

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: tpalanee@wrhi.ac.za

Affiliations Wits Reproductive Health and HIV Institute (Wits RHI), University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa, Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America

https://orcid.org/0000-0002-0052-5830

⨯
Helen V. Rees ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Wits Reproductive Health and HIV Institute (Wits RHI), University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa

https://orcid.org/0000-0003-1442-6734

⨯
Kate B. Heller ,

Contributed equally to this work with: Thesla Palanee-Phillips, Kate B. Heller, Jared M. Baeten

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Khatija Ahmed ,

Roles Data curation, Investigation, Methodology, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Setshaba Research Centre, Soshanguve, South Africa

https://orcid.org/0000-0003-0309-1641

⨯
Joanne Batting ,

Roles Data curation, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Effective Care Research Unit (ECRU), University of the Witwatersrand/Fort Hare, East London, South Africa
⨯
Ivana Beesham ,

Roles Conceptualization, Data curation, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa
⨯
Renee Heffron ,

Roles Conceptualization, Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Jessica Justman ,

Roles Data curation, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Mailman School of Public Health, ICAP at Columbia University, New York, New York, United States of America
⨯
Heeran Makkan ,

Roles Data curation, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Klerksdorp Clinical Research Centre, The Aurum Institute, Johannesburg, South Africa

https://orcid.org/0000-0002-4737-7804

⨯
Timothy D. Mastro ,

Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation FHI 360, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-9307-0360

⨯
Susan A. Morrison ,

Roles Data curation, Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Nelly Mugo ,

Roles Data curation, Funding acquisition, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliations Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Kenya Medical Research Institute (KEMRI), Nairobi, Kenya
⨯
Gonasagrie Nair ,

Roles Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliations Emavundleni Research Centre, University of Cape Town, Cape Town, South Africa, Department of Medicine, Faculty of Medicine and Health Sciences, Centre for Medical Ethics and Law, Stellenbosch University, Stellenbosch, South Africa
⨯
James Kiarie ,

Roles Funding acquisition, Investigation, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneva, Switzerland
⨯
Neena M. Philip ,

Roles Data curation, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Mailman School of Public Health, ICAP at Columbia University, New York, New York, United States of America
⨯
Melanie Pleaner ,

Roles Data curation, Investigation, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Wits Reproductive Health and HIV Institute (Wits RHI), University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa
⨯
Krishnaveni Reddy ,

Roles Data curation, Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Wits Reproductive Health and HIV Institute (Wits RHI), University of the Witwatersrand, Faculty of Health Sciences, Johannesburg, South Africa
⨯
Pearl Selepe ,

Roles Data curation, Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Klerksdorp Clinical Research Centre, The Aurum Institute, Johannesburg, South Africa
⨯
Petrus S. Steyn ,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), World Health Organization, Geneva, Switzerland
⨯
Caitlin W. Scoville ,

Roles Conceptualization, Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Gilead Sciences, Foster City, California, United States of America
⨯
Jenni Smit ,

Roles Data curation, Investigation, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Department of Obstetrics and Gynaecology, Faculty of Health Sciences, University of the Witwatersrand, Durban, South Africa
⨯
Katherine K. Thomas ,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Deborah Donnell ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

¶‡ HVR, KA, JB, IB, RH, JJ, HM, TDM, SAM, NM, GN, JK, NMP, MP, KR, PS, PSS, CWS, JS, KKT and DD also contributed equally to this work.

Affiliation Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Jared M. Baeten ,

Contributed equally to this work with: Thesla Palanee-Phillips, Kate B. Heller, Jared M. Baeten

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, Washington, United States of America, Gilead Sciences, Foster City, California, United States of America
⨯
[ ... ],
for the ECHO Trial Consortium

¶ECHO Trial Consortium is listed in the Acknowledgments.
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High HIV incidence among young women in South Africa: Data from a large prospective study

Thesla Palanee-Phillips,
Helen V. Rees,
Kate B. Heller,
Khatija Ahmed,
Joanne Batting,
Ivana Beesham,
Renee Heffron,
Jessica Justman,
Heeran Makkan,
Timothy D. Mastro

Published: June 3, 2022
https://doi.org/10.1371/journal.pone.0269317

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