Assessment of the percentage of full recombinant adeno-associated virus particles in a gene therapy drug using CryoTEM

• Mathieu Colomb-Delsuc ,

  Contributed equally to this work with: Mathieu Colomb-Delsuc, Roman Raim

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mathieu.colomb-delsuc@vironova.com

  Affiliation Vironova AB, Stockholm, Sweden

  https://orcid.org/0000-0003-1100-1028

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• Roman Raim ,

  Contributed equally to this work with: Mathieu Colomb-Delsuc, Roman Raim

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Baxalta Innovations GmbH, A Part of Takeda Companies, Orth an der Donau, Austria

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• Christian Fiedler,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Baxalta Innovations GmbH, A Part of Takeda Companies, Orth an der Donau, Austria

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• Stefan Reuberger,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Baxalta Innovations GmbH, A Part of Takeda Companies, Orth an der Donau, Austria

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• Johannes Lengler,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Baxalta Innovations GmbH, A Part of Takeda Companies, Orth an der Donau, Austria

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• Rickard Nordström,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliation Vironova AB, Stockholm, Sweden

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• Martin Ryner,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Vironova AB, Stockholm, Sweden

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• Ioana Mihaela Folea,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Vironova AB, Stockholm, Sweden

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• Barbara Kraus,

  Roles Conceptualization, Project administration, Resources, Validation, Writing – review & editing

  Affiliation Baxalta Innovations GmbH, A Part of Takeda Companies, Orth an der Donau, Austria

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• Juan A. Hernandez Bort,

  Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Baxalta Innovations GmbH, A Part of Takeda Companies, Orth an der Donau, Austria

  https://orcid.org/0000-0003-2348-4864

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• Ida-Maria Sintorn

  Roles Conceptualization, Investigation, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Vironova AB, Stockholm, Sweden, Department of Information Technology, Uppsala University, Uppsala, Sweden

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