Gene prioritization based on random walks with restarts and absorbing states, to define gene sets regulating drug pharmacodynamics from single-cell analyses

Augusto Sales de Queiroz; Guilherme Sales Santa Cruz; Alain Jean-Marie; Dorian Mazauric; Jérémie Roux; Frédéric Cazals

doi:10.1371/journal.pone.0268956

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Open Access

Peer-reviewed

Research Article

Gene prioritization based on random walks with restarts and absorbing states, to define gene sets regulating drug pharmacodynamics from single-cell analyses

Augusto Sales de Queiroz ,

Contributed equally to this work with: Augusto Sales de Queiroz, Guilherme Sales Santa Cruz

Roles Conceptualization, Software, Validation, Visualization

Affiliation Inria, Université Côte d’Azur, Nice, France
⨯
Guilherme Sales Santa Cruz ,

Contributed equally to this work with: Augusto Sales de Queiroz, Guilherme Sales Santa Cruz

Roles Conceptualization, Software, Validation, Visualization

Affiliation Inria, Université Côte d’Azur, Nice, France
⨯
Alain Jean-Marie,

Roles Conceptualization, Methodology, Software

Affiliation Inria, Université de Montpellier, Montpellier, France

https://orcid.org/0000-0002-9210-4530

⨯
Dorian Mazauric,

Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

Affiliation Inria, Université Côte d’Azur, Nice, France

https://orcid.org/0000-0002-5589-1889

⨯
Jérémie Roux ,

Roles Conceptualization, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Frederic.Cazals@inria.fr (FC); jeremie.roux@univ-cotedazur.fr (JR)

Affiliation CNRS UMR 7284, Inserm U 1081, Institut de Recherche sur le Cancer et le Vieillissement de Nice, Centre Antoine Lacassagne, Universite Côte d’Azur, Nice, France

https://orcid.org/0000-0001-5712-8660

⨯
Frédéric Cazals

Roles Conceptualization, Formal analysis, Methodology, Software, Supervision, Writing – original draft, Writing – review & editing

* E-mail: Frederic.Cazals@inria.fr (FC); jeremie.roux@univ-cotedazur.fr (JR)

Affiliation Inria, Université Côte d’Azur, Nice, France

https://orcid.org/0000-0003-2735-6755

⨯

Gene prioritization based on random walks with restarts and absorbing states, to define gene sets regulating drug pharmacodynamics from single-cell analyses

Augusto Sales de Queiroz,
Guilherme Sales Santa Cruz,
Alain Jean-Marie,
Dorian Mazauric,
Jérémie Roux,
Frédéric Cazals

Published: November 7, 2022
https://doi.org/10.1371/journal.pone.0268956
See the preprint

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Gene expression
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Random walk
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Drug interactions
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Gene regulation
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Markov models
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Drug therapy
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Protein interaction networks
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