Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins

• Sarah A. Yunes,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, Program in Molecular Biology, Cell Biology, and Biochemistry, Boston University, Boston, Massachusetts, United States of America

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• Jennifer L. S. Willoughby,

  Roles Conceptualization, Investigation, Visualization

  Affiliations Program in Molecular Biology, Cell Biology, and Biochemistry, Boston University, Boston, Massachusetts, United States of America, Alnylam Pharmaceuticals, Cambridge, Massachusetts, United States of America

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• Julian H. Kwan,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Biochemistry and Center for Network Systems Biology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Jessica M. Biagi,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Chemistry and Center for Molecular Discovery, Boston University, Boston, Massachusetts, United States of America

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• Niranjana Pokharel,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Department of Chemistry and Center for Molecular Discovery, Boston University, Boston, Massachusetts, United States of America

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• Hang Gyeong Chin,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliations Program in Molecular Biology, Cell Biology, and Biochemistry, Boston University, Boston, Massachusetts, United States of America, New England Biolabs, Ipswich, Massachusetts, United States of America

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• Emily A. York,

  Roles Investigation

  Affiliation Department of Chemistry and Center for Molecular Discovery, Boston University, Boston, Massachusetts, United States of America

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• Kuan-Chung Su,

  Roles Formal analysis, Methodology

  Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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• Kelly George,

  Roles Investigation, Visualization

  Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Jagesh V. Shah,

  Roles Conceptualization

  Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Andrew Emili,

  Roles Funding acquisition, Supervision

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, Department of Biochemistry and Center for Network Systems Biology, Boston University School of Medicine, Boston, Massachusetts, United States of America

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• Scott E. Schaus,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision

  Affiliation Department of Chemistry and Center for Molecular Discovery, Boston University, Boston, Massachusetts, United States of America

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• Ulla Hansen

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: uhansen@bu.edu

  Affiliations Department of Biology, Boston University, Boston, Massachusetts, United States of America, Program in Molecular Biology, Cell Biology, and Biochemistry, Boston University, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-9803-4185

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