Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium

J. E. Siland; B. Geelhoed; C. Roselli; B. Wang; H. J. Lin; S. Weiss; S. Trompet; M. E. van den Berg; E. Z. Soliman; L. Y. Chen; I. Ford; J. W. Jukema; P. W. Macfarlane; J. Kornej; H. Lin; K. L. Lunetta; M. Kavousi; J. A. Kors; M. A. Ikram; X. Guo; J. Yao; M. Dörr; S. B. Felix; U. Völker; N. Sotoodehnia; D. E. Arking; B. H. Stricker; S. R. Heckbert; S. A. Lubitz; E. J. Benjamin; A. Alonso; P. T. Ellinor; P. van der Harst; M. Rienstra

doi:10.1371/journal.pone.0268768

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Open Access

Peer-reviewed

Research Article

Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium

J. E. Siland,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Visualization, Writing – original draft

Affiliation Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
⨯
B. Geelhoed,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

Affiliation Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
⨯
C. Roselli,

Roles Formal analysis, Methodology, Resources, Writing – review & editing

Affiliations Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, United States of America
⨯
B. Wang,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America
⨯
H. J. Lin,

Roles Formal analysis, Resources, Writing – review & editing

Affiliations Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, United States of America, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America
⨯
S. Weiss,

Roles Formal analysis, Resources, Writing – review & editing

Affiliations Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine Greifswald, Greifswald, Germany, DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany

https://orcid.org/0000-0002-3553-4315

⨯
S. Trompet,

Roles Formal analysis, Resources, Writing – review & editing

Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
⨯
M. E. van den Berg,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
⨯
E. Z. Soliman,

Roles Formal analysis, Methodology, Resources, Writing – review & editing

Affiliation Division of Public Health Sciences and Department of Medicine, Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, NC, United States of America
⨯
L. Y. Chen,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, United States of America
⨯
I. Ford,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
⨯
J. W. Jukema,

Roles Supervision, Writing – review & editing

Affiliations DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany, Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, The Netherlands, Netherlands Heart Institute, Utrecht, The Netherlands
⨯
P. W. Macfarlane,

Roles Supervision, Writing – review & editing

Affiliation Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
J. Kornej,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation National Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, United States of America
⨯
H. Lin,

Roles Formal analysis, Resources, Writing – review & editing

Affiliations National Heart Lung and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, United States of America, Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, Unites States of America
⨯
K. L. Lunetta,

Roles Formal analysis, Resources, Writing – review & editing

Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, National Heart, Lung, and Blood Institute’s and Boston University’s Framingham Heart Study, Framingham, MA, United States of America

https://orcid.org/0000-0002-9268-810X

⨯
M. Kavousi,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
⨯
J. A. Kors,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Department of Medical Informatics, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
⨯
M. A. Ikram,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
⨯
X. Guo,

Roles Formal analysis, Resources, Writing – review & editing

Affiliations Institute for Translational Genomics and Population Sciences, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, United States of America, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America
⨯
J. Yao,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, United States of America
⨯
M. Dörr,

Roles Resources, Writing – review & editing

Affiliations DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany, Department of Internal Medicine B-Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany
⨯
S. B. Felix,

Roles Formal analysis, Resources

Affiliations DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany, Department of Internal Medicine B-Cardiology, Pneumology, Infectious Diseases, Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany
⨯
U. Völker,

Roles Formal analysis, Resources, Supervision

Affiliations Interfaculty Institute for Genetics and Functional Genomics; Department of Functional Genomics; University Medicine Greifswald, Greifswald, Germany, DZHK (German Centre for Cardiovascular Research); partner site Greifswald, Greifswald, Germany
⨯
N. Sotoodehnia,

Roles Formal analysis, Resources

Affiliation Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, Unites States of America
⨯
D. E. Arking,

Roles Formal analysis, Methodology, Resources

Affiliation McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University SOM, Baltimore, MD, Unites States of America
⨯
B. H. Stricker,

Roles Resources, Supervision

Affiliation Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
⨯
S. R. Heckbert,

Roles Resources, Supervision

Affiliation Cardiovascular Health Research Unit and the Department of Epidemiology, University of Washington, Seattle, WA, Unites States of America

https://orcid.org/0000-0002-7100-512X

⨯
S. A. Lubitz,

Roles Methodology, Resources, Supervision

Affiliations Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, Unites States of America, Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, Unites States of America

https://orcid.org/0000-0002-9599-4866

⨯
E. J. Benjamin,

Roles Methodology, Resources, Supervision

Affiliations Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Department of Medicine, Boston University School of Medicine, Boston, MA, Unites States of America, Department of Epidemiology, Boston University School of Public Health, Boston, MA, Unites States of America
⨯
A. Alonso,

Roles Formal analysis, Resources, Supervision, Writing – review & editing

Affiliation Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, Unites States of America

https://orcid.org/0000-0002-2225-8323

⨯
P. T. Ellinor,

Roles Formal analysis, Resources, Supervision, Writing – review & editing

Affiliations Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA, United States of America, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, Unites States of America, Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, Unites States of America
⨯
P. van der Harst,

Roles Conceptualization, Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands, University Medical Center Utrecht, Department of Heart and Lungs, University of Utrecht, Utrecht, The Netherlands
⨯
[ ... ],
M. Rienstra

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

* E-mail: m.rienstra@umcg.nl

Affiliation Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

https://orcid.org/0000-0002-2581-070X

⨯
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Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium

J. E. Siland,
B. Geelhoed,
C. Roselli,
B. Wang,
H. J. Lin,
S. Weiss,
S. Trompet,
M. E. van den Berg,
E. Z. Soliman,
L. Y. Chen

Published: May 20, 2022
https://doi.org/10.1371/journal.pone.0268768

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