Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9)

Tomoko Honda; Norihito Kawasaki; Rei Yanagihara; Ryo Tamura; Karin Murakami; Tomomi Ichimiya; Naoki Matsumoto; Shoko Nishihara; Kazuo Yamamoto

doi:10.1371/journal.pone.0268485

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Open Access

Peer-reviewed

Research Article

Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9)

Tomoko Honda,

Roles Data curation, Formal analysis

Affiliation Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
⨯
Norihito Kawasaki,

Roles Data curation, Formal analysis

Affiliation Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
⨯
Rei Yanagihara,

Roles Data curation, Formal analysis

Affiliation Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
⨯
Ryo Tamura,

Roles Data curation, Formal analysis

Affiliation Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

https://orcid.org/0000-0002-9681-5735

⨯
Karin Murakami,

Roles Data curation, Formal analysis

Affiliation Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
⨯
Tomomi Ichimiya,

Roles Data curation, Formal analysis

Affiliation Department of Bioinformatics, Graduate School of Engineering, Soka University, Hachioji, Tokyo, Japan
⨯
Naoki Matsumoto,

Roles Supervision

Affiliation Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan
⨯
Shoko Nishihara,

Roles Supervision

Affiliations Department of Bioinformatics, Graduate School of Engineering, Soka University, Hachioji, Tokyo, Japan, Glycan & Life System Integration Center (GaLSIC), Soka University, Hachioji, Tokyo, Japan
⨯
Kazuo Yamamoto

Roles Funding acquisition, Project administration, Writing – original draft

* E-mail: yamamoto@edu.k.u-tokyo.ac.jp

Affiliation Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

https://orcid.org/0000-0001-7466-2443

⨯

Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9)

Tomoko Honda,
Norihito Kawasaki,
Rei Yanagihara,
Ryo Tamura,
Karin Murakami,
Tomomi Ichimiya,
Naoki Matsumoto,
Shoko Nishihara,
Kazuo Yamamoto

Published: July 28, 2022
https://doi.org/10.1371/journal.pone.0268485

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Heparin
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Point mutation
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Disaccharides
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Inner ear
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Polymerase chain reaction
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Deafness
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Sulfates
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