Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium

Yue Li; Shawn Gappy; Xiuli Liu; Therese Sassalos; Tongrong Zhou; Andrew Hsu; Alice Zhang; Paul A. Edwards; Hua Gao; Xiaoxi Qiao

doi:10.1371/journal.pone.0268451

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Open Access

Peer-reviewed

Research Article

Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium

Yue Li ,

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

* E-mail: doctoryueli@gmail.com

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America

https://orcid.org/0000-0002-3015-7581

⨯
Shawn Gappy,

Roles Data curation, Investigation

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Xiuli Liu,

Roles Data curation, Investigation, Methodology

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Therese Sassalos,

Roles Data curation, Investigation

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Tongrong Zhou,

Roles Data curation, Investigation, Methodology

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Andrew Hsu,

Roles Data curation, Investigation, Methodology

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Alice Zhang,

Roles Data curation, Investigation

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Paul A. Edwards,

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Hua Gao,

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯
Xiaoxi Qiao

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Department of Ophthalmology, Henry Ford Hospital, Detroit, Michigan, United States of America
⨯

Metformin suppresses pro-inflammatory cytokines in vitreous of diabetes patients and human retinal vascular endothelium

Yue Li,
Shawn Gappy,
Xiuli Liu,
Therese Sassalos,
Tongrong Zhou,
Andrew Hsu,
Alice Zhang,
Paul A. Edwards,
Hua Gao,
Xiaoxi Qiao

Published: July 8, 2022
https://doi.org/10.1371/journal.pone.0268451

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Inflammation
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