Progesterone receptor expression contributes to gemcitabine resistance at higher ECM stiffness in breast cancer cell lines

Emma Grant; Fatma A. Bucklain; Lucy Ginn; Peter Laity; Barbara Ciani; Helen E. Bryant

doi:10.1371/journal.pone.0268300

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Open Access

Peer-reviewed

Research Article

Progesterone receptor expression contributes to gemcitabine resistance at higher ECM stiffness in breast cancer cell lines

Emma Grant,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Department of Oncology and Metabolism, Academic Unit of Molecular Oncology, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, United Kingdom, Department of Chemistry, Centre for Membrane Interactions and Dynamics (CMIAD), Krebs Institute, University of Sheffield, Sheffield, United Kingdom
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Fatma A. Bucklain,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Oncology and Metabolism, Academic Unit of Molecular Oncology, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, United Kingdom
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Lucy Ginn,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Current address: Cell Signalling Group, Cancer Research UK Manchester Institute, University of Manchester, Alderley Park, Manchester, United Kingdom

Affiliation Department of Oncology and Metabolism, Academic Unit of Molecular Oncology, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, United Kingdom
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Peter Laity,

Roles Methodology, Supervision, Writing – review & editing

Affiliation Department of Materials Science and Engineering, Natural Materials Group, Sheffield, United Kingdom
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Barbara Ciani,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Materials Science and Engineering, Natural Materials Group, Sheffield, United Kingdom
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Helen E. Bryant

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: h.bryant@sheffield.ac.uk

Affiliation Department of Oncology and Metabolism, Academic Unit of Molecular Oncology, Sheffield Institute for Nucleic Acids (SInFoNiA), University of Sheffield, Sheffield, United Kingdom

https://orcid.org/0000-0003-2720-7020

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Progesterone receptor expression contributes to gemcitabine resistance at higher ECM stiffness in breast cancer cell lines

Emma Grant,
Fatma A. Bucklain,
Lucy Ginn,
Peter Laity,
Barbara Ciani,
Helen E. Bryant

Published: May 26, 2022
https://doi.org/10.1371/journal.pone.0268300

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Breast cancer
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Gels
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Cancer treatment
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Stiffness
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Polyacrylamides
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Progesterone
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