A novel 3-acyl isoquinolin-1(2H)-one induces G2 phase arrest, apoptosis and GSDME-dependent pyroptosis in breast cancer

• Lei Ma,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P. R. China

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• Mengyao Bian,

  Roles Investigation, Methodology

  Affiliation Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P. R. China

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• Hui Gao,

  Roles Formal analysis, Writing – review & editing

  Affiliation Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P. R. China

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• Zhi Zhou ,

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: yiwei@gzhmu.edu.cn (WY); zhouzhi@gzhmu.edu.cn (ZZ)

  Affiliation Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P. R. China

  https://orcid.org/0000-0002-6521-8946

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• Wei Yi

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: yiwei@gzhmu.edu.cn (WY); zhouzhi@gzhmu.edu.cn (ZZ)

  Affiliation Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation & Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P. R. China

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