Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

Sabine Matou-Nasri; Maria Najdi; Nouran Abu AlSaud; Yazeid Alhaidan; Hamad Al-Eidi; Ghada Alatar; Deemah AlWadaani; Thadeo Trivilegio; Arwa AlSubait; Abeer AlTuwaijri; Manal Abudawood; Bader Almuzzaini

doi:10.1371/journal.pone.0267855

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Open Access

Peer-reviewed

Research Article

Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

Sabine Matou-Nasri ,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: matouepnasrisa@ngha.med.sa (SMN); MuzzainiB@ngha.med.sa (BA)

Affiliation Cell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

https://orcid.org/0000-0003-4372-2903

⨯
Maria Najdi,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Cell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia, Postgraduate program, King Saud University, Riyadh, Saudi Arabia
⨯
Nouran Abu AlSaud,

Roles Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliation Department of Cellular Therapy and Cancer Research, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
⨯
Yazeid Alhaidan,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
⨯
Hamad Al-Eidi,

Roles Data curation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Cell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

https://orcid.org/0000-0002-8495-7111

⨯
Ghada Alatar,

Roles Data curation, Formal analysis, Methodology, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliation Cell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

https://orcid.org/0000-0002-9023-7452

⨯
Deemah AlWadaani,

Roles Data curation, Formal analysis, Methodology, Project administration, Software, Validation, Visualization, Writing – review & editing

Affiliation Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

https://orcid.org/0000-0001-6536-0777

⨯
Thadeo Trivilegio,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Medical Research Core Facility and Platforms, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
⨯
Arwa AlSubait,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Medical Research Core Facility and Platforms, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

https://orcid.org/0000-0002-6006-2356

⨯
Abeer AlTuwaijri,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia
⨯
Manal Abudawood,

Roles Data curation, Methodology, Project administration, Software, Validation, Visualization, Writing – review & editing

Affiliation Department of Clinical Laboratory Sciences, Chair of Medical and Molecular Genetics Research, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
⨯
Bader Almuzzaini

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: matouepnasrisa@ngha.med.sa (SMN); MuzzainiB@ngha.med.sa (BA)

Affiliation Medical Genomics Research Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia

https://orcid.org/0000-0003-1176-9037

⨯

Blockade of p38 MAPK overcomes AML stem cell line KG1a resistance to 5-Fluorouridine and the impact on miRNA profiling

Sabine Matou-Nasri,
Maria Najdi,
Nouran Abu AlSaud,
Yazeid Alhaidan,
Hamad Al-Eidi,
Ghada Alatar,
Deemah AlWadaani,
Thadeo Trivilegio,
Arwa AlSubait,
Abeer AlTuwaijri

Published: May 5, 2022
https://doi.org/10.1371/journal.pone.0267855

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