Clustering ICU patients with sepsis based on the patterns of their circulating biomarkers: A secondary analysis of the CAPTAIN prospective multicenter cohort study

• Benoît Misset ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: benoit.misset@chuliege.be

  Affiliations Intensive Care Department, Liège University Hospital, Liège, Belgium, Infection, Immunity and Inflammation Research Unit, GIGA I3, Liège University, Liège, Belgium

  https://orcid.org/0000-0001-6466-0065

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• François Philippart,

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Service de Médecine Intensive et Réanimation, Groupe Hospitalier Paris Saint-Joseph, Paris, France, Unité Endotoxines, Structures et Réponse de l’Hôte, Département de Microbiologie, Institut de Biologie Intégrative de la Cellule, Paris Saclay, Saclay, France

  https://orcid.org/0000-0002-7323-0742

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• Catherine Fitting,

  Roles Data curation, Project administration

  Affiliation Unit Cytokines & Inflammation, Institut Pasteur, Paris, France

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• Jean-Pierre Bedos,

  Roles Data curation

  Affiliation Service de Réanimation, Hôpital André Mignot, Versailles, France

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• Jean-Luc Diehl,

  Roles Data curation

  Affiliations Service de Réanimation Médicale, Hôpital Européen Georges Pompidou, Assistance Publique—Hôpitaux de Paris, Paris, France, INSERM UMR S1140, Université Paris Descartes, Paris Sorbonne Cité, Paris, France

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• Olfa Hamzaoui,

  Roles Data curation

  Affiliation Service de Réanimation, Hôpital Antoine Béclère, Assistance Publique—Hôpitaux de Paris, Clamart, France

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• Djillali Annane,

  Roles Data curation, Writing – review & editing

  Affiliations Service de Réanimation, Hôpital Raymond Poincaré, Assistance Publique—Hôpitaux de Paris, Garches, France, Université Versailles Saint-Quentin, Versailles, France

  https://orcid.org/0000-0001-6805-8944

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• Didier Journois,

  Roles Data curation

  Affiliation Service de Réanimation Chirurgicale, Hôpital Européen Georges Pompidou, Assistance Publique—Hôpitaux de Paris, Paris, France

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• Marianna Parlato,

  Roles Data curation, Formal analysis

  Affiliation Unit Cytokines & Inflammation, Institut Pasteur, Paris, France

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• Virginie Moucadel,

  Roles Data curation, Formal analysis, Funding acquisition, Writing – review & editing

  Affiliation BioMérieux SA, Lyon, France

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• Jean-Marc Cavaillon,

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Unit Cytokines & Inflammation, Institut Pasteur, Paris, France

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• Joël Coste,

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Unité de Biostatistiques et d’Epidémiologie, Hôpital Cochin, Assistance Publique—Hôpitaux de Paris, Paris, France, Université de Paris, Paris, France

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• for the CAPTAIN Study Group

  ¶Members of the Combined Approach for The eArly diagnosis of INfection in sepsis (CAPTAIN) study group is provided in the Acknowledgments (collaborators section).

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