The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis

Aiyun Li; Wenjuan Shi; Jin Wang; Xuejiao Wang; Yan Zhang; Zhandong Lei; Xiang-Ying Jiao

doi:10.1371/journal.pone.0267331

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Peer-reviewed

Research Article

The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis

Aiyun Li ,

Contributed equally to this work with: Aiyun Li, Wenjuan Shi

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and The Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯
Wenjuan Shi ,

Contributed equally to this work with: Aiyun Li, Wenjuan Shi

Roles Conceptualization, Investigation, Methodology, Writing – original draft

Affiliation Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and The Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯
Jin Wang,

Roles Project administration, Resources, Validation

Affiliation Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and The Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯
Xuejiao Wang,

Roles Investigation, Software

Affiliation Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and The Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯
Yan Zhang,

Roles Software, Validation

Affiliation Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and The Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯
Zhandong Lei,

Roles Data curation, Software

Affiliation Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and The Department of Physiology, Shanxi Medical University, Taiyuan, China
⨯
Xiang-Ying Jiao

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: jiaoxy@sxmu.edu.cn

Affiliation Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and The Department of Physiology, Shanxi Medical University, Taiyuan, China

https://orcid.org/0000-0003-1182-9052

⨯

The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis

Aiyun Li,
Wenjuan Shi,
Jin Wang,
Xuejiao Wang,
Yan Zhang,
Zhandong Lei,
Xiang-Ying Jiao

Published: July 8, 2022
https://doi.org/10.1371/journal.pone.0267331

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Adipose tissue
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Diet
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Obesity
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Lipolysis
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Gene knockout
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Fatty acids
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