Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

• Muhammad Ali,

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0002-1399-6631

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• Yun Ju Sung,

  Roles Data curation

  Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0002-8021-4070

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• Fengxian Wang,

  Roles Data curation

  Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0002-7677-5406

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• Maria V. Fernández,

  Roles Data curation

  Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• John C. Morris,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Anne M. Fagan,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Kaj Blennow,

  Roles Project administration, Writing – review & editing

  Affiliations Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden, Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden

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• Henrik Zetterberg,

  Roles Project administration, Writing – review & editing

  Affiliations Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden, Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom, UK Dementia Research Institute at UCL, London, United Kingdom

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• Amanda Heslegrave,

  Roles Project administration, Writing – review & editing

  Affiliations Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom, UK Dementia Research Institute at UCL, London, United Kingdom

  https://orcid.org/0000-0002-7290-6405

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• Per M. Johansson,

  Roles Project administration, Writing – review & editing

  Affiliations Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom, UK Dementia Research Institute at UCL, London, United Kingdom, Department of Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, Mölndal, Sweden, Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

  https://orcid.org/0000-0003-0073-7654

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• Johan Svensson,

  Roles Project administration, Writing – review & editing

  Affiliation Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden

  https://orcid.org/0000-0002-4487-6405

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• Bengt Nellgård,

  Roles Project administration, Writing – review & editing

  Affiliation Department of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, Göteborg, Sweden

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• Alberto Lleó,

  Roles Project administration, Writing – review & editing

  Affiliation Neurology Department, Hospital de Sant Pau, Barcelona, Spain

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• Daniel Alcolea,

  Roles Project administration, Writing – review & editing

  Affiliation Neurology Department, Hospital de Sant Pau, Barcelona, Spain

  https://orcid.org/0000-0002-3819-3245

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• Jordi Clarimon,

  Roles Project administration, Writing – review & editing

  Affiliation Neurology Department, Hospital de Sant Pau, Barcelona, Spain

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• Lorena Rami,

  Roles Project administration, Writing – review & editing

  Affiliation IDIBAPS, Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain

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• José Luis Molinuevo,

  Roles Project administration, Writing – review & editing

  Affiliations IDIBAPS, Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic, Barcelona, Spain, Alzheimer´s Disease and Other Cognitive Disorders Unit, Neurology Service, ICN Hospital Clinic i Universitari, Barcelona, Spain, BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain

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• Marc Suárez-Calvet,

  Roles Project administration, Writing – review & editing

  Affiliations BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain, Biomedical Center (BMC), Biochemistry, Ludwig‐Maximilians‐Universität München, Munich, Germany, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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• Estrella Morenas-Rodríguez,

  Roles Project administration, Writing – review & editing

  Affiliations Biomedical Center (BMC), Biochemistry, Ludwig‐Maximilians‐Universität München, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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• Gernot Kleinberger,

  Roles Project administration, Writing – review & editing

  Affiliations Biomedical Center (BMC), Biochemistry, Ludwig‐Maximilians‐Universität München, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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• Christian Haass,

  Roles Project administration, Writing – review & editing

  Affiliations Biomedical Center (BMC), Biochemistry, Ludwig‐Maximilians‐Universität München, Munich, Germany, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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• Michael Ewers,

  Roles Project administration, Writing – review & editing

  Affiliation Institute for Stroke and Dementia Research, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany

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• Johannes Levin,

  Roles Project administration, Writing – review & editing

  Affiliations German Center for Neurodegenerative Diseases (DZNE), Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany

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• Martin R. Farlow,

  Roles Project administration, Writing – review & editing

  Affiliations Indiana Alzheimer Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Richard J. Perrin,

  Roles Project administration, Writing – review & editing

  Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0002-3443-7716

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• on behalf of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) ,

  ¶Membership of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Dominantly Inherited Alzheimer Network (DIAN) is provided in the Acknowledgments.

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• on behalf of the Dominantly Inherited Alzheimer Network (DIAN) ,

  ¶Membership of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Dominantly Inherited Alzheimer Network (DIAN) is provided in the Acknowledgments.

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•  [ ... ],
• Carlos Cruchaga

  Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – review & editing

  * E-mail: cruchagc@psychiatry.wustl.edu

  Affiliations Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, Neurogenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America

  https://orcid.org/0000-0002-0276-2899

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