Integration of bioassay and non-target metabolite analysis of tomato reveals that β-carotene and lycopene activate the adiponectin signaling pathway, including AMPK phosphorylation

• Shinsuke Mohri,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Laboratory of Technology of Marine Bioproducts, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

  https://orcid.org/0000-0002-9083-2913

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• Haruya Takahashi ,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft

  * E-mail: takahashi.haruya.3x@kyoto-u.ac.jp (HT); shibata.daisuke.h93@kyoto-u.jp (DS); goto.tsuyoshi.6x@kyoto-u.ac.jp (TG)

  Affiliations Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

  https://orcid.org/0000-0003-3182-2894

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• Maiko Sakai,

  Roles Investigation, Validation

  Affiliation Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

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• Naoko Waki,

  Roles Investigation, Methodology, Resources, Validation, Visualization

  Affiliations KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Innovation Division, KAGOME CO., LTD., Tochigi, Japan

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• Shingo Takahashi,

  Roles Methodology, Resources

  Affiliation Innovation Division, KAGOME CO., LTD., Tochigi, Japan

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• Koichi Aizawa,

  Roles Resources

  Affiliation Innovation Division, KAGOME CO., LTD., Tochigi, Japan

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• Hiroyuki Suganuma,

  Roles Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Innovation Division, KAGOME CO., LTD., Tochigi, Japan

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• Takeshi Ara,

  Roles Data curation, Formal analysis, Investigation, Validation

  Affiliation KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

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• Tatsuya Sugawara,

  Roles Supervision, Writing – review & editing

  Affiliation Laboratory of Technology of Marine Bioproducts, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

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• Daisuke Shibata ,

  Roles Project administration, Supervision, Writing – review & editing

  * E-mail: takahashi.haruya.3x@kyoto-u.ac.jp (HT); shibata.daisuke.h93@kyoto-u.jp (DS); goto.tsuyoshi.6x@kyoto-u.ac.jp (TG)

  Affiliations KAGOME Tomato Discoveries Laboratory, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Kazusa DNA Research Institutes, Kazusa-Kamatari, Chiba, Japan

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• Yasuki Matsumura,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliation Laboratory of Quality Analysis and Assessment, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

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• Tsuyoshi Goto ,

  Roles Funding acquisition, Project administration, Writing – review & editing

  * E-mail: takahashi.haruya.3x@kyoto-u.ac.jp (HT); shibata.daisuke.h93@kyoto-u.jp (DS); goto.tsuyoshi.6x@kyoto-u.ac.jp (TG)

  Affiliations Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Research Unit for Physiological Chemistry, Kyoto University, Kyoto, Japan

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• Teruo Kawada

  Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliations Laboratory of Molecular Function of Food, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Research Unit for Physiological Chemistry, Kyoto University, Kyoto, Japan

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