BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved anti-cell line derived tumor xenograft activity

• Taylor L. Hickman ,

  Contributed equally to this work with: Taylor L. Hickman, Eugene Choi, Kathleen R. Whiteman

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Eugene Choi ,

  Contributed equally to this work with: Taylor L. Hickman, Eugene Choi, Kathleen R. Whiteman

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Kathleen R. Whiteman ,

  Contributed equally to this work with: Taylor L. Hickman, Eugene Choi, Kathleen R. Whiteman

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America, SOTIO Biotech Inc

  ⨯
• Sujatha Muralidharan,

  Roles Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation SOTIO Biotech Inc

  ⨯
• Tapasya Pai,

  Roles Data curation, Investigation, Visualization, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Tyler Johnson,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Avani Parikh,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Taylor Friedman,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Madaline Gilbert,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Binzhang Shen,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Luke Barron,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Kathleen E. McGinness,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Seth A. Ettenberg,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Greg T. Motz,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America

  ⨯
• Glen J. Weiss ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: weiss@sotio.com (GJW); jensen-smith@sotio.com (AJS)

  Affiliations Unum Therapeutics, Inc., Cambridge, Massachusetts, United States of America, SOTIO Biotech Inc

  https://orcid.org/0000-0002-6067-597X

  ⨯
•  [ ... ],
• Amy Jensen-Smith

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: weiss@sotio.com (GJW); jensen-smith@sotio.com (AJS)

  Affiliation SOTIO Biotech Inc

  ⨯
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