Efficacy assessment of a novel endolysin PlyAZ3a^T for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model

• Luca G. Valente,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Institute for Infectious Diseases, University of Bern, Bern, Switzerland, Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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• Ngoc Dung Le,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute for Infectious Diseases, University of Bern, Bern, Switzerland, Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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• Melissa Pitton,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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• Gabriele Chiffi,

  Roles Investigation, Writing – review & editing

  Affiliations Institute for Infectious Diseases, University of Bern, Bern, Switzerland, Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland

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• Denis Grandgirard,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Institute for Infectious Diseases, University of Bern, Bern, Switzerland

  https://orcid.org/0000-0002-4151-5196

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• Stephan M. Jakob,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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• David R. Cameron,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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• Grégory Resch,

  Roles Investigation, Writing – review & editing

  Affiliation Centre for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital, Lausanne, Switzerland

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• Yok-Ai Que,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

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• Stephen L. Leib

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: stephen.leib@ifik.unibe.ch

  Affiliation Institute for Infectious Diseases, University of Bern, Bern, Switzerland

  https://orcid.org/0000-0002-1106-6123

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