Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain

Abida Shaheen; Syed Mahboob Alam; Fahad Azam; Salman Ahmad Saleem; Moosa Khan; Syed Saud Hasan; Afrose Liaquat

doi:10.1371/journal.pone.0266559

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Open Access

Peer-reviewed

Research Article

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain

Abida Shaheen ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: abida.scm@stmu.edu.pk

Affiliation Department of Pharmacology & Therapeutics, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan

https://orcid.org/0000-0001-8977-9820

⨯
Syed Mahboob Alam,

Roles Conceptualization, Data curation, Methodology, Project administration, Writing – review & editing

Affiliation Department of Pharmacology & Therapeutics, Basic Medical Sciences Institute, JPMC, Karachi, Pakistan
⨯
Fahad Azam,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Pharmacology & Therapeutics, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan
⨯
Salman Ahmad Saleem,

Roles Conceptualization, Data curation, Methodology, Project administration, Writing – review & editing

Affiliation Department of Pain Clinic, Shifa International Hospital, Islamabad, Pakistan
⨯
Moosa Khan,

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Pharmacology & Therapeutics, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan
⨯
Syed Saud Hasan,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Pharmacology & Therapeutics, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan
⨯
Afrose Liaquat

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Biochemistry, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan

https://orcid.org/0000-0001-6410-6953

⨯

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain

Abida Shaheen,
Syed Mahboob Alam,
Fahad Azam,
Salman Ahmad Saleem,
Moosa Khan,
Syed Saud Hasan,
Afrose Liaquat

Published: May 13, 2022
https://doi.org/10.1371/journal.pone.0266559

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Neuropathic pain
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Variant genotypes
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Human genetics
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Drug absorption
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Single nucleotide polymorphisms
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Pain
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Genetic polymorphism
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Pharmacokinetics
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