Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5’ splice site: Generation of etoposide resistance in human leukemia K562 cells

• Victor A. Hernandez,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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• Jessika Carvajal-Moreno,

  Roles Conceptualization, Data curation, Formal analysis

  Affiliation Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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• Xinyi Wang,

  Roles Conceptualization, Data curation, Formal analysis

  Affiliation Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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• Maciej Pietrzak,

  Roles Data curation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, United States of America

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• Jack C. Yalowich ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: Yalowich.1@osu.edu (JCY); Elton.8@osu.edu (TSE)

  Affiliation Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

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• Terry S. Elton

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: Yalowich.1@osu.edu (JCY); Elton.8@osu.edu (TSE)

  Affiliation Division of Pharmaceutics and Pharmacology, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America

  https://orcid.org/0000-0001-8034-8741

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