Disruptions in hepatic glucose metabolism are involved in the diminished efficacy after chronic treatment with glucokinase activator

• Yoshinori Tsumura ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Writing – original draft

  * E-mail: y.tsumura@teijin.co.jp

  Current address: Pharmaceutical Development Coordination Department, Teijin Pharma Limited, Chiyoda, Tokyo, Japan

  Affiliation Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan

  https://orcid.org/0000-0002-7223-6018

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• Yu Tsushima,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan

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• Azusa Tamura,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan

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• Hirotsugu Kato,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Current address: Legal and Intellectual Property Strategy Department, Teijin Pharma Limited, Hino, Tokyo, Japan

  Affiliation Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan

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• Tsunefumi Kobayashi

  Roles Project administration, Supervision, Writing – review & editing

  Current address: Research, Development & Technology Unit, Teijin Pharma Limited, Chiyoda, Tokyo, Japan

  Affiliation Pharmacology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, Hino, Tokyo, Japan

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