The effects of antibiotic cycling and mixing on acquisition of antibiotic resistant bacteria in the ICU: A post-hoc individual patient analysis of a prospective cluster-randomized crossover study

• Pleun J. van Duijn ,

  Roles Data curation, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: joppe.vanduijn@gmail.com

  Affiliation Department of Epidemiology, Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands

  https://orcid.org/0000-0003-4881-0355

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• Walter Verbrugghe,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium

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• Philippe G. Jorens,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium

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• Fabian Spöhr,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Anaesthesiology and Intensive Care, Sana Kliniken Stuttgart, Stuttgart, Germany

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• Dirk Schedler,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Anaesthesiology and Intensive Care, Sana Kliniken Stuttgart, Stuttgart, Germany

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• Maria Deja,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

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• Andreas Rothbart,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Anesthesiology and Operative Intensive Care Medicine, Charité Universitätsmedizin, Berlin, Germany

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• Djillali Annane,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Department of Intensive Care, Hôpital Raymond Poincaré (APHP), Garches, France, Laboratory of Infection & Inflammation, School of Medicine Simone Veil, University Versailles Saint Quentin & University Paris Saclay, INSERM, Montigny le Bretonneux, France, FHU SEPSIS (Saclay and Paris Seine Nord Endeavour to PerSonalize Interventions for Sepsis) and RHU RECORDS (Rapid rEcognition of CORticosteroiD resistant or sensitive Sepsis), Garches, France

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• Christine Lawrence,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Microbiology Unit, Raymond-Poincaré Hospital, Garches, France

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• Matjaz Jereb,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Department of Infectious Diseases, University Medical Centre, Ljubljana, Slovenia, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia

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• Katja Seme,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Ljubljana, Slovenia

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• Franc Šifrer,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Intensive Care Medicine, University Hospital Golnik, Golnik, Slovenia

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• Viktorija Tomič,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Medical Microbiology, University Hospital Golnik, Golnik, Slovenia

  https://orcid.org/0000-0003-4806-1024

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• Francisco Estevez,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Intensive Care Unit and Emergency Department, Centro Hospitalar Trás-os-Montes e Alto Douro, Vila Real, Portugal

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• Jandira Carneiro,

  Roles Investigation, Methodology, Resources

  Affiliation Intensive Care Unit and Emergency Department, Centro Hospitalar Trás-os-Montes e Alto Douro, Vila Real, Portugal

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• Stephan Harbarth,

  Roles Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

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•  [ ... ],
• Marc J. M. Bonten

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Epidemiology, Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands, Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands

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