Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity

• Ponsiree Jithavech,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok, Thailand, Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

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• Piyapan Suwattananuruk,

  Roles Investigation, Writing – original draft

  Affiliations Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok, Thailand, Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

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• Hasriadi,

  Roles Investigation, Visualization, Writing – original draft

  Affiliation Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

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• Chawanphat Muangnoi,

  Roles Formal analysis, Writing – original draft

  Affiliation Cell and Animal Model Unit, Institute of Nutrition, Mahidol University, Nakhon Pathom, Thailand

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• Worathat Thitikornpong,

  Roles Supervision, Writing – review & editing

  Affiliations Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok, Thailand, Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

  https://orcid.org/0000-0002-3537-3646

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• Pasarapa Towiwat,

  Roles Supervision, Writing – review & editing

  Affiliations Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok, Thailand, Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

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• Opa Vajragupta,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliations Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok, Thailand, Research Affairs, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

  https://orcid.org/0000-0003-3313-0621

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• Pornchai Rojsitthisak

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: pornchai.r@chula.ac.th

  Affiliations Center of Excellence in Natural Products for Ageing and Chronic Diseases, Chulalongkorn University, Bangkok, Thailand, Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

  https://orcid.org/0000-0003-1391-6993

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