Calculating and comparing codon usage values in rare disease genes highlights codon clustering with disease-and tissue- specific hierarchy

• Rachele Rossi ,

  Contributed equally to this work with: Rachele Rossi, Mingyan Fang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft

  Affiliations Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, Dubowitz Neuromuscular Unit, Institute of Child Health, University College London, London, United Kingdom

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• Mingyan Fang ,

  Contributed equally to this work with: Rachele Rossi, Mingyan Fang

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliation BGI-Shenzhen, Shenzhen, China

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• Lin Zhu,

  Roles Data curation, Formal analysis, Methodology

  Affiliations BGI-Shenzhen, Shenzhen, China, BGI College & Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China

  https://orcid.org/0000-0001-6249-1245

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• Chongyi Jiang,

  Roles Funding acquisition, Supervision, Validation

  Affiliation BGI-Shenzhen, Shenzhen, China

  ⨯
• Cong Yu,

  Roles Funding acquisition, Supervision, Validation

  Affiliation BGI Genomics, BGI-Shenzhen, Shenzhen, China

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• Cristina Flesia,

  Roles Formal analysis, Supervision

  Affiliation Department of Earth and Environment Science, University of Milano-Bicocca, Milano, Italy

  https://orcid.org/0000-0002-8275-3545

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• Chao Nie,

  Roles Funding acquisition, Supervision, Validation

  Affiliation BGI-Shenzhen, Shenzhen, China

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• Wenyan Li,

  Roles Funding acquisition, Supervision, Validation

  Affiliation MGI, BGI-Shenzhen, Shenzhen, China

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• Alessandra Ferlini

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: fla@unife.it

  Affiliations Unit of Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, Dubowitz Neuromuscular Unit, Institute of Child Health, University College London, London, United Kingdom

  https://orcid.org/0000-0001-8385-9870

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