Performance characteristics of the first Food and Drug Administration (FDA)-cleared digital droplet PCR (ddPCR) assay for BCR::ABL1 monitoring in chronic myelogenous leukemia

Dawne N. Shelton; Prasanthi Bhagavatula; Nathan Sepulveda; Lan Beppu; Shital Gandhi; Dahui Qin; Scott Hauenstein; Jerald Radich

doi:10.1371/journal.pone.0265278

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Open Access

Peer-reviewed

Research Article

Performance characteristics of the first Food and Drug Administration (FDA)-cleared digital droplet PCR (ddPCR) assay for BCR::ABL1 monitoring in chronic myelogenous leukemia

Dawne N. Shelton,

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Digital Biology Group, Bio-Rad Laboratories, Pleasanton, California, United States of America
⨯
Prasanthi Bhagavatula ,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

* E-mail: jradich@fredhutch.org (JR); prasanthi_bhagavatula@bio-rad.com (PB)

Affiliation Digital Biology Group, Bio-Rad Laboratories, Pleasanton, California, United States of America

https://orcid.org/0000-0002-4442-7220

⨯
Nathan Sepulveda,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

Affiliation Digital Biology Group, Bio-Rad Laboratories, Pleasanton, California, United States of America
⨯
Lan Beppu,

Roles Investigation, Project administration, Resources, Validation

Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Shital Gandhi,

Roles Investigation, Resources, Validation

Affiliation Department of Pathology, Moffitt Cancer Center, Tampa, Florida, United States of America
⨯
Dahui Qin,

Roles Investigation, Resources, Validation

Affiliation Department of Pathology, Moffitt Cancer Center, Tampa, Florida, United States of America
⨯
Scott Hauenstein,

Roles Writing – original draft

Affiliation Digital Biology Group, Bio-Rad Laboratories, Pleasanton, California, United States of America
⨯
Jerald Radich

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: jradich@fredhutch.org (JR); prasanthi_bhagavatula@bio-rad.com (PB)

Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯

Performance characteristics of the first Food and Drug Administration (FDA)-cleared digital droplet PCR (ddPCR) assay for BCR::ABL1 monitoring in chronic myelogenous leukemia

Dawne N. Shelton,
Prasanthi Bhagavatula,
Nathan Sepulveda,
Lan Beppu,
Shital Gandhi,
Dahui Qin,
Scott Hauenstein,
Jerald Radich

Published: March 17, 2022
https://doi.org/10.1371/journal.pone.0265278

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