Large-scale design and refinement of stable proteins using sequence-only models

• Jedediah M. Singer ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jed.singer@twosixtech.com

  Affiliation Two Six Technologies, Arlington, Virginia, United States of America

  https://orcid.org/0000-0002-5255-4473

  ⨯
• Scott Novotney,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Two Six Technologies, Arlington, Virginia, United States of America

  ⨯
• Devin Strickland,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America

  ⨯
• Hugh K. Haddox,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
• Nicholas Leiby,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Visualization, Writing – review & editing

  Affiliation Two Six Technologies, Arlington, Virginia, United States of America

  ⨯
• Gabriel J. Rocklin,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Pharmacology and Center for Synthetic Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

  ⨯
• Cameron M. Chow,

  Roles Investigation, Project administration, Visualization, Writing – review & editing

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0001-5351-6412

  ⨯
• Anindya Roy,

  Roles Investigation, Project administration, Visualization, Writing – review & editing

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
• Asim K. Bera,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
• Francis C. Motta,

  Roles Data curation, Funding acquisition, Methodology, Software, Writing – review & editing

  Affiliation Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, Florida, United States of America

  https://orcid.org/0000-0002-0364-5440

  ⨯
• Longxing Cao,

  Roles Data curation, Resources

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
• Eva-Maria Strauch,

  Roles Data curation, Resources

  Affiliation Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia, United States of America

  ⨯
• Tamuka M. Chidyausiku,

  Roles Data curation, Resources

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-2561-782X

  ⨯
• Alex Ford,

  Roles Data curation, Resources

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
• Ethan Ho,

  Roles Methodology, Software, Validation

  Affiliation Texas Advanced Computing Center, Austin, Texas, United States of America

  https://orcid.org/0000-0002-7070-3321

  ⨯
• Alexander Zaitzeff,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Two Six Technologies, Arlington, Virginia, United States of America

  ⨯
• Craig O. Mackenzie,

  Roles Data curation, Methodology, Software

  Affiliation Quantitative Biomedical Sciences Graduate Program, Dartmouth College, Hanover, New Hampshire, United States of America

  ⨯
• Hamed Eramian,

  Roles Data curation

  Affiliation Netrias, Cambridge, Massachusetts, United States of America

  ⨯
• Frank DiMaio,

  Roles Formal analysis

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
• Gevorg Grigoryan,

  Roles Data curation, Methodology, Software

  Affiliation Departments of Computer Science and Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

  ⨯
• Matthew Vaughn,

  Roles Funding acquisition, Supervision

  Affiliation Texas Advanced Computing Center, Austin, Texas, United States of America

  https://orcid.org/0000-0002-1384-4283

  ⨯
• Lance J. Stewart,

  Roles Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
• David Baker,

  Roles Conceptualization, Funding acquisition, Supervision

  Affiliation Department of Biochemistry and Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

  ⨯
•  [ ... ],
• Eric Klavins

  Roles Conceptualization, Funding acquisition, Supervision

  Affiliation Department of Electrical and Computer Engineering, University of Washington, Seattle, Washington, United States of America

  ⨯
• [ view all ]
• [ view less ]