Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls

Lotte Simonsen; Jesper Lau; Thomas Kruse; Tingqing Guo; Jim McGuire; Jacob Fuglsbjerg Jeppesen; Kristoffer Niss; Per Sauerberg; Kirsten Raun; Charlotta Dornonville de la Cour

doi:10.1371/journal.pone.0264974

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Open Access

Peer-reviewed

Research Article

Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls

Lotte Simonsen,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Global Obesity & Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
⨯
Jesper Lau,

Roles Conceptualization, Resources, Visualization, Writing – review & editing

Affiliation Research Chemistry, Novo Nordisk A/S, Måløv, Denmark
⨯
Thomas Kruse,

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Research Chemistry, Novo Nordisk A/S, Måløv, Denmark
⨯
Tingqing Guo,

Roles Formal analysis, Investigation, Methodology

Affiliation Discovery Biology, Novo Nordisk Research Centre, Beijing, China
⨯
Jim McGuire,

Roles Formal analysis, Investigation, Visualization, Writing – review & editing

Current address: Translational Research, Catalyst Biosciences, San Francisco, CA, United States of America

Affiliation Incretin Biology, Novo Nordisk A/S, Måløv, Denmark
⨯
Jacob Fuglsbjerg Jeppesen,

Roles Formal analysis, Writing – review & editing

Affiliation Global Diabetes, Cardio- & Renal Research, Novo Nordisk A/S, Måløv, Denmark
⨯
Kristoffer Niss,

Roles Investigation, Visualization

Affiliation Bioinformatics & Data Mining, Novo Nordisk A/S, Måløv, Denmark

https://orcid.org/0000-0001-5910-1525

⨯
Per Sauerberg,

Roles Conceptualization, Project administration

Affiliation Project and Alliance Management, Novo Nordisk A/S, Måløv, Denmark
⨯
Kirsten Raun,

Roles Writing – review & editing

Affiliation Global Obesity & Liver Disease Research, Novo Nordisk A/S, Måløv, Denmark
⨯
Charlotta Dornonville de la Cour

Roles Conceptualization, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: cddc@novonordisk.com

Affiliation Global Diabetes, Cardio- & Renal Research, Novo Nordisk A/S, Måløv, Denmark

https://orcid.org/0000-0003-1047-4755

⨯

Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls

Lotte Simonsen,
Jesper Lau,
Thomas Kruse,
Tingqing Guo,
Jim McGuire,
Jacob Fuglsbjerg Jeppesen,
Kristoffer Niss,
Per Sauerberg,
Kirsten Raun,
Charlotta Dornonville de la Cour

Published: March 4, 2022
https://doi.org/10.1371/journal.pone.0264974

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