Investigation of the active ingredients and pharmacological mechanisms of Porana sinensis Hemsl. Against rheumatoid arthritis using network pharmacology and experimental validation

Jing Hu; Lintao Zhao; Ning Li; Yuanyuan Yang; Tong Qu; Hui Ren; Xiaomin Cui; Hongxun Tao; Zhiyong Chen; Yu Peng

doi:10.1371/journal.pone.0264786

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Open Access

Peer-reviewed

Research Article

Investigation of the active ingredients and pharmacological mechanisms of Porana sinensis Hemsl. Against rheumatoid arthritis using network pharmacology and experimental validation

Jing Hu ,

Contributed equally to this work with: Jing Hu, Lintao Zhao

Roles Data curation, Investigation

Affiliation Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, China
⨯
Lintao Zhao ,

Contributed equally to this work with: Jing Hu, Lintao Zhao

Roles Investigation

Affiliation Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, China
⨯
Ning Li ,

Roles Investigation

* E-mail: gsshxln@163.com (NL); chenzhiyong0612@sina.com (ZC); carlylepeng@gmail.com (YP)

Affiliation Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, China
⨯
Yuanyuan Yang,

Roles Data curation

Affiliation Department of Traditional Chinese Medicine, Xi’an Institute for Food and Drug Control, Xi’an, China
⨯
Tong Qu,

Roles Data curation

Affiliation Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, China
⨯
Hui Ren,

Roles Validation

Affiliation Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, China
⨯
Xiaomin Cui,

Roles Validation

Affiliation Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, China
⨯
Hongxun Tao,

Roles Writing – review & editing

Affiliation School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
⨯
Zhiyong Chen ,

Roles Project administration, Writing – original draft

* E-mail: gsshxln@163.com (NL); chenzhiyong0612@sina.com (ZC); carlylepeng@gmail.com (YP)

Affiliation Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi’an, China

https://orcid.org/0000-0002-4868-2237

⨯
Yu Peng

Roles Writing – review & editing

* E-mail: gsshxln@163.com (NL); chenzhiyong0612@sina.com (ZC); carlylepeng@gmail.com (YP)

Affiliation Jiangsu Provincial Key Laboratory of Cardiovascular and Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, China
⨯

Investigation of the active ingredients and pharmacological mechanisms of Porana sinensis Hemsl. Against rheumatoid arthritis using network pharmacology and experimental validation

Jing Hu,
Lintao Zhao,
Ning Li,
Yuanyuan Yang,
Tong Qu,
Hui Ren,
Xiaomin Cui,
Hongxun Tao,
Zhiyong Chen,
Yu Peng

Published: March 2, 2022
https://doi.org/10.1371/journal.pone.0264786

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