Human IL-2Rɑ subunit binding modulation of IL-2 through a decline in electrostatic interactions: A computational and experimental approach

• Arezoo Beig Parikhani ,

  Roles Investigation, Software, Writing – original draft

  ¶‡ ABP and RD contributed equally to this work as co-first authors

  Affiliations Venom and Biotherapeutics Molecules Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran, Student Research Committee, Pasteur Institute of Iran, Tehran, Iran

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• Kowsar Bagherzadeh,

  Roles Project administration, Software, Writing – review & editing

  Affiliations Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran, Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

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• Rada Dehghan ,

  Roles Investigation, Writing – original draft

  ¶‡ ABP and RD contributed equally to this work as co-first authors

  Affiliations Venom and Biotherapeutics Molecules Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran, Student Research Committee, Pasteur Institute of Iran, Tehran, Iran

  ⨯
• Alireza Biglari,

  Roles Conceptualization

  Affiliation School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

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• Mohammad Ali Shokrgozar,

  Roles Conceptualization

  Affiliation National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran

  https://orcid.org/0000-0002-9198-4070

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• Farhad Riazi Rad,

  Roles Methodology

  Affiliation Department of Immunology, Pasteur Institute of Iran, Tehran, Iran

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• Sirous Zeinali,

  Roles Conceptualization, Supervision

  Affiliation Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

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• Yeganeh Talebkhan,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

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• Soheila Ajdary ,

  Roles Supervision, Writing – review & editing

  * E-mail: behdani73042@yahoo.com, behdani@pasteur.ac.ir (MB); cohan_r@yahoo.com (RAC); ajdsoh@pasteur.ac.ir (SA)

  Affiliation Department of Immunology, Pasteur Institute of Iran, Tehran, Iran

  https://orcid.org/0000-0002-5052-2523

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• Reza Ahangari Cohan ,

  Roles Conceptualization, Writing – review & editing

  * E-mail: behdani73042@yahoo.com, behdani@pasteur.ac.ir (MB); cohan_r@yahoo.com (RAC); ajdsoh@pasteur.ac.ir (SA)

  Affiliation Department of Nanobiotechnology, New Technologies Research Group, Pasteur Institute of Iran, Tehran, Iran

  https://orcid.org/0000-0002-0490-4184

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• Mahdi Behdani

  Roles Supervision, Writing – review & editing

  * E-mail: behdani73042@yahoo.com, behdani@pasteur.ac.ir (MB); cohan_r@yahoo.com (RAC); ajdsoh@pasteur.ac.ir (SA)

  Affiliation Venom and Biotherapeutics Molecules Laboratory, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

  https://orcid.org/0000-0002-4839-5123

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