Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models

Raza Jamal; Jonathan LaCombe; Roshni Patel; Matthew Blackwell; Jared R. Thomas; Kourtney Sloan; Joseph M. Wallace; Randall J. Roper

doi:10.1371/journal.pone.0264254

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Open Access

Peer-reviewed

Research Article

Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models

Raza Jamal,

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America
⨯
Jonathan LaCombe,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America
⨯
Roshni Patel,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America
⨯
Matthew Blackwell,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America
⨯
Jared R. Thomas,

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America
⨯
Kourtney Sloan,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America
⨯
Joseph M. Wallace,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America
⨯
Randall J. Roper

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: rjroper@iupui.edu

Affiliation Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana, United States of America

https://orcid.org/0000-0002-9860-5037

⨯

Increased dosage and treatment time of Epigallocatechin-3-gallate (EGCG) negatively affects skeletal parameters in normal mice and Down syndrome mouse models

Raza Jamal,
Jonathan LaCombe,
Roshni Patel,
Matthew Blackwell,
Jared R. Thomas,
Kourtney Sloan,
Joseph M. Wallace,
Randall J. Roper

Published: February 23, 2022
https://doi.org/10.1371/journal.pone.0264254

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