Long-term high-fructose high-fat diet feeding elicits insulin resistance, exacerbates dyslipidemia and induces gut microbiota dysbiosis in WHHL rabbits

Michelle Moughaizel; Elie Dagher; Amin Jablaoui; Chantal Thorin; Moez Rhimi; Jean-Claude Desfontis; Yassine Mallem

doi:10.1371/journal.pone.0264215

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Open Access

Peer-reviewed

Research Article

Long-term high-fructose high-fat diet feeding elicits insulin resistance, exacerbates dyslipidemia and induces gut microbiota dysbiosis in WHHL rabbits

Michelle Moughaizel ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

* E-mail: m_moughaizel@hotmail.com (MM); yassine.mallem@oniris-nantes.fr (YM)

Affiliation Nutrition, PathoPhysiology and Pharmacology (NP3) Unit, Oniris, Nantes Atlantic College of Veterinary Medicine, Food Science and Engineering, Nantes, France

https://orcid.org/0000-0001-8394-272X

⨯
Elie Dagher,

Roles Conceptualization, Methodology, Software, Validation

Affiliation Laboniris, Oniris, Nantes Atlantic College of Veterinary Medicine, Food Science and Engineering, Nantes, France
⨯
Amin Jablaoui,

Roles Formal analysis, Software

Affiliation Institut Micalis, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Chantal Thorin,

Roles Data curation, Software, Validation

Affiliation Nutrition, PathoPhysiology and Pharmacology (NP3) Unit, Oniris, Nantes Atlantic College of Veterinary Medicine, Food Science and Engineering, Nantes, France
⨯
Moez Rhimi,

Roles Formal analysis, Software, Validation, Writing – review & editing

Affiliation Institut Micalis, INRAE, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Jean-Claude Desfontis,

Roles Project administration, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Nutrition, PathoPhysiology and Pharmacology (NP3) Unit, Oniris, Nantes Atlantic College of Veterinary Medicine, Food Science and Engineering, Nantes, France
⨯
Yassine Mallem

Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: m_moughaizel@hotmail.com (MM); yassine.mallem@oniris-nantes.fr (YM)

Affiliation Nutrition, PathoPhysiology and Pharmacology (NP3) Unit, Oniris, Nantes Atlantic College of Veterinary Medicine, Food Science and Engineering, Nantes, France
⨯

Long-term high-fructose high-fat diet feeding elicits insulin resistance, exacerbates dyslipidemia and induces gut microbiota dysbiosis in WHHL rabbits

Michelle Moughaizel,
Elie Dagher,
Amin Jablaoui,
Chantal Thorin,
Moez Rhimi,
Jean-Claude Desfontis,
Yassine Mallem

Published: February 23, 2022
https://doi.org/10.1371/journal.pone.0264215

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Rabbits
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Gut bacteria
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Diet
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Insulin
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Glucose metabolism
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Blood plasma
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