FOXP3 and CXCR4-positive regulatory T cells in the tumor stroma as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment

Mizuki Tagami; Anna Kakehashi; Atsuko Katsuyama-Yoshikawa; Norihiko Misawa; Atsushi Sakai; Hideki Wanibuchi; Atsushi Azumi; Shigeru Honda

doi:10.1371/journal.pone.0263895

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Open Access

Peer-reviewed

Research Article

FOXP3 and CXCR4-positive regulatory T cells in the tumor stroma as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment

Mizuki Tagami ,

Roles Conceptualization, Formal analysis, Investigation, Project administration, Writing – original draft

* E-mail: tagami.mizuki@med.osaka-cu.ac.jp

Affiliations Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan, Ophthalmology Department and Eye Center, Kobe Kaisei Hospital, Kobe, Hyogo, Japan

https://orcid.org/0000-0002-8771-7252

⨯
Anna Kakehashi,

Roles Data curation, Formal analysis, Supervision

Affiliation Department of Molecular Pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan

https://orcid.org/0000-0003-1149-1450

⨯
Atsuko Katsuyama-Yoshikawa,

Roles Data curation, Formal analysis, Visualization

Affiliations Ophthalmology Department and Eye Center, Kobe Kaisei Hospital, Kobe, Hyogo, Japan, Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo, Japan
⨯
Norihiko Misawa,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan
⨯
Atsushi Sakai,

Roles Data curation, Formal analysis, Investigation

Affiliation Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan

https://orcid.org/0000-0001-8399-6082

⨯
Hideki Wanibuchi,

Roles Supervision, Writing – review & editing

Affiliation Department of Molecular Pathology, Graduate School of Medicine, Osaka City University, Osaka, Japan
⨯
Atsushi Azumi,

Roles Supervision, Writing – review & editing

Affiliation Ophthalmology Department and Eye Center, Kobe Kaisei Hospital, Kobe, Hyogo, Japan
⨯
Shigeru Honda

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, Osaka, Japan
⨯

FOXP3 and CXCR4-positive regulatory T cells in the tumor stroma as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment

Mizuki Tagami,
Anna Kakehashi,
Atsuko Katsuyama-Yoshikawa,
Norihiko Misawa,
Atsushi Sakai,
Hideki Wanibuchi,
Atsushi Azumi,
Shigeru Honda

Published: March 31, 2022
https://doi.org/10.1371/journal.pone.0263895

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Ocular tumors
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