Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

Patricia Sansilvestri Morel; Valerie Duvivier; Florence Bertin; Nicolas Provost; Adel Hammoutene; Edwige-Ludiwyne Hubert; Arantxa Gonzalez; Isabelle Tupinon-Mathieu; Valerie Paradis; Philippe Delerive

doi:10.1371/journal.pone.0263828

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Open Access

Peer-reviewed

Research Article

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

Patricia Sansilvestri Morel ,

Roles Conceptualization, Writing – original draft

* E-mail: patricia.sansilvestri-morel@servier.com

Affiliation Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France

https://orcid.org/0000-0003-3685-4473

⨯
Valerie Duvivier,

Roles Conceptualization, Methodology

Affiliation Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France
⨯
Florence Bertin,

Roles Methodology

Affiliation Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France
⨯
Nicolas Provost,

Roles Methodology

Affiliation Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France
⨯
Adel Hammoutene,

Roles Methodology

Affiliations Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France, Pathology Department, Hôpital Beaujon, Paris, France

https://orcid.org/0000-0001-6928-7431

⨯
Edwige-Ludiwyne Hubert,

Roles Methodology

Affiliation Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France
⨯
Arantxa Gonzalez,

Roles Investigation

Affiliation Program of Cardiovascular Diseases, CIMA Universidad de Navarra, IdiSNA and CIBERCV, Pamplona, Spain
⨯
Isabelle Tupinon-Mathieu,

Roles Supervision

Affiliation Cardiovascular and Metabolic Diseases, Institut de Recherches Internationales Servier, Suresnes, France
⨯
Valerie Paradis,

Roles Supervision

Affiliation Pathology Department, Hôpital Beaujon, Paris, France
⨯
Philippe Delerive

Roles Conceptualization, Writing – original draft

Affiliation Cardiovascular and Metabolic Diseases Research, Institut de Recherches Servier, Suresnes, France
⨯

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

Patricia Sansilvestri Morel,
Valerie Duvivier,
Florence Bertin,
Nicolas Provost,
Adel Hammoutene,
Edwige-Ludiwyne Hubert,
Arantxa Gonzalez,
Isabelle Tupinon-Mathieu,
Valerie Paradis,
Philippe Delerive

Published: February 11, 2022
https://doi.org/10.1371/journal.pone.0263828

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