Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation

Prabu Paramasivam; Emmanuelle Meugnier; Kuppan Gokulakrishnan; Harish Ranjini; Lisa R. Staimez; Mary Beth Weber; K. M. Venkat Narayan; Hubert Vidal; Nikhil Tandon; Dorairaj Prabhakaran; Anjana Ranjit Mohan; Viswanathan Mohan; Sophie Rome; Muthuswamy Balasubramanyam

doi:10.1371/journal.pone.0263479

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Open Access

Peer-reviewed

Research Article

Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation

Prabu Paramasivam,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Madras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control & IDF Centre of Education, Gopalapuram, Chennai, India, Department of Neurology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, United States of America
⨯
Emmanuelle Meugnier,

Roles Data curation, Formal analysis, Investigation, Software, Writing – review & editing

Affiliation CarMeN Laboratory, French National Institute of Health and Medical Research (INSERM) U1060, National Research Institute for Agriculture, Food and Environment (INRAE) U1397, University of Lyon, Claude Bernard University Lyon 1, Oullins, France
⨯
Kuppan Gokulakrishnan,

Roles Formal analysis, Resources, Writing – review & editing

Affiliation Department of Neurochemistry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India
⨯
Harish Ranjini,

Roles Formal analysis, Investigation

Affiliation Madras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control & IDF Centre of Education, Gopalapuram, Chennai, India
⨯
Lisa R. Staimez,

Roles Conceptualization, Formal analysis

Affiliation Emory University, Atlanta, GA, United States of America
⨯
Mary Beth Weber,

Roles Formal analysis, Investigation

Affiliation Emory University, Atlanta, GA, United States of America
⨯
K. M. Venkat Narayan,

Roles Investigation

Affiliation Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India
⨯
Hubert Vidal,

Roles Formal analysis

Affiliation CarMeN Laboratory, French National Institute of Health and Medical Research (INSERM) U1060, National Research Institute for Agriculture, Food and Environment (INRAE) U1397, University of Lyon, Claude Bernard University Lyon 1, Oullins, France
⨯
Nikhil Tandon,

Roles Investigation

Affiliation Centre for Chronic Disease Control and Public Health Foundation of India, New Delhi, India
⨯
Dorairaj Prabhakaran,

Roles Investigation

Affiliation Centre for Chronic Disease Control and Public Health Foundation of India, New Delhi, India
⨯
Anjana Ranjit Mohan,

Roles Funding acquisition, Investigation, Project administration

Affiliation Madras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control & IDF Centre of Education, Gopalapuram, Chennai, India
⨯
Viswanathan Mohan,

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources

Affiliation Madras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control & IDF Centre of Education, Gopalapuram, Chennai, India
⨯
Sophie Rome ,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: balumentor@gmail.com (MB); srome@univ-lyon1.fr (SR)

¶‡ Co-last authors.

Affiliation CarMeN Laboratory, French National Institute of Health and Medical Research (INSERM) U1060, National Research Institute for Agriculture, Food and Environment (INRAE) U1397, University of Lyon, Claude Bernard University Lyon 1, Oullins, France

https://orcid.org/0000-0003-3986-5936

⨯
Muthuswamy Balasubramanyam

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: balumentor@gmail.com (MB); srome@univ-lyon1.fr (SR)

¶‡ Co-last authors.

Affiliations Madras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control & IDF Centre of Education, Gopalapuram, Chennai, India, Medical & Health Sciences (MHS), SRM Institute of Science and Technology (SRMIST), Chennai, India
⨯

Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation

Prabu Paramasivam,
Emmanuelle Meugnier,
Kuppan Gokulakrishnan,
Harish Ranjini,
Lisa R. Staimez,
Mary Beth Weber,
K. M. Venkat Narayan,
Hubert Vidal,
Nikhil Tandon,
Dorairaj Prabhakaran

Published: February 4, 2022
https://doi.org/10.1371/journal.pone.0263479

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