Specific patterns of vital sign fluctuations predict infection and enable sepsis diagnosis in pediatric burn patients

Farzin Sadeq; Jonah Poster; Chris Chu; Joan Weber; Martha Lydon; Maggie Dylewski Begis; Robert Leo Sheridan; Korkut Uygun

doi:10.1371/journal.pone.0263421

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Open Access

Peer-reviewed

Research Article

Specific patterns of vital sign fluctuations predict infection and enable sepsis diagnosis in pediatric burn patients

Farzin Sadeq,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-9101-2397

⨯
Jonah Poster,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Icahn School of Medicine at Mount Sinai, New York City, New York, United States of America
⨯
Chris Chu,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joan Weber,

Roles Writing – review & editing

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Martha Lydon,

Roles Writing – review & editing

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Maggie Dylewski Begis,

Roles Writing – review & editing

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-0598-5905

⨯
Robert Leo Sheridan ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

* E-mail: kuygun@mgh.harvard.edu (KU); rsheridan@mgh.harvard.edu (RLS)

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Korkut Uygun

Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

* E-mail: kuygun@mgh.harvard.edu (KU); rsheridan@mgh.harvard.edu (RLS)

Affiliations Department of Research, Shriners Hospitals for Children Boston, Boston, Massachusetts, United States of America, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-2088-7860

⨯

Specific patterns of vital sign fluctuations predict infection and enable sepsis diagnosis in pediatric burn patients

Farzin Sadeq,
Jonah Poster,
Chris Chu,
Joan Weber,
Martha Lydon,
Maggie Dylewski Begis,
Robert Leo Sheridan,
Korkut Uygun

Published: February 7, 2022
https://doi.org/10.1371/journal.pone.0263421

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