Evaluating the detection ability of a range of epistasis detection methods on simulated data for pure and impure epistatic models

• Dominic Russ ,

  Contributed equally to this work with: Dominic Russ, John A. Williams

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  * E-mail: drr719@bham.ac.uk

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0002-2705-2068

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• John A. Williams ,

  Contributed equally to this work with: Dominic Russ, John A. Williams

  Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0002-0357-5454

  ⨯
• Victor Roth Cardoso,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0002-9588-6304

  ⨯
• Laura Bravo-Merodio,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom

  ⨯
• Samantha C. Pendleton,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom

  ⨯
• Furqan Aziz,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0002-0906-1323

  ⨯
• Animesh Acharjee ,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  ¶‡ AA and GVG also contributed equally to this work.

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom, NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdoma

  ⨯
• Georgios V. Gkoutos

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  ¶‡ AA and GVG also contributed equally to this work.

  Affiliations Institute of Cancer and Genomic Sciences, Centre for Computational Biology, University of Birmingham, Birmingham, United Kingdom, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom, NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, United Kingdoma, MRC Health Data Research UK (HDR UK) Birmingham, United Kingdom, NIHR Experimental Cancer Medicine Centre, Birmingham, United Kingdom

  https://orcid.org/0000-0002-2061-091X

  ⨯